2026-03-15T20:05:50Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02004008 2025-04-28T06:01:33Z 1713829974766:1713854681789:1716364518663:1716421309759 1713853213384:1713853295607

A/G heterozygote of the A-3826G polymorphism in the UCP-1 gene has higher BMI than A/A and G/G homozygote in young Japanese males ナカノ, タクロウ ナカノ, タクロウ Nakano, Takuro 新家, 利一 シンカ, トシカツ Shinka, Toshikatsu 勢井, 雅子 セイ, マサコ Sei, Masako 10363160 佐藤, 陽一 サトウ, ヨウイチ Sato, Youichi 佐藤 サトウ Sato 陽一 ヨウイチ Youichi 梅野, 真由美 ウメノ, マユミ Umeno, Mayumi サカモト, コズエ サカモト, コズエ Sakamoto, Kozue 野村, 以徂子 ノムラ, イソコ Nomura, Isoko 中堀, 豊 ナカホリ, ユタカ Nakahori, Yutaka open access UCP-1 A-3826G polymorphism Japanese young male obesity UCP-1 is suggested to have important roles for thermogenesis and energy expenditure. To elucidate whether the A-3826G polymorphism that is located in the 5’ flanking region of the UCP-1 gene has roles in healthy young people, the polymorphism was genotyped among 251 young Japanese men whose mean age is 22.7 years old. We analyzed relationship between the A-3826G polymorphism and body mass index (BMI) or six biochemical parameters, serum concentration of total cholesterol (TC), high density lipoprotein (HDL) cholesterol, triglyceride (TG), asparatate aminotransferase (AST), alanine aminotransferase (ALT), fasting plasma glucose. The genotype frequencies were observed at the frequencies of 24.3% for AA, 48.2% for AG and 27.5% for GG, respectively. When BMI and the biochemical parameters were compared by ANOVA among individuals with each genotype, the statistical difference was observed only for BMI (P=0.016). Bonferroni’s test demonstrated that the men with the AG genotype have higher BMI than those with the AA genotype (22.4±2.8 vs. 21.4±2.2)(P=0.04). The individuals with the AG genotype also showed trend to have higher BMI than those with the GG, although the difference was not statistically apparent (22.4±2.8 vs. 21.5±2.3) (P=0.07). Our results indicated that the young healthy Japanese men with the AG heterozygote showed higher BMI than those with other genotypes. 2006-08 eng journal article VoR 160591 https://tokushima-u.repo.nii.ac.jp/records/2004008 13431420 AA11166929 The journal of medical investigation : JMI 53 3-4 218 222 https://tokushima-u.repo.nii.ac.jp/record/2004008/files/jmi_53_3-4_218.pdf application/pdf 63.3 KB 2017-12-07