2026-03-10T03:49:12Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02004165 2025-04-28T06:28:40Z 1713853213384:1713853295607

Anti-Inflammatory Effects of Rebamipide Eyedrop Administration on Ocular Lesions in a Murine Model of Primary Sjögren’s Syndrome 00193061 新垣, 理恵子 アラカキ, リエコ Arakaki, Rieko 新垣 アラカキ Arakaki 理恵子 リエコ Rieko 30314868 江口, 洋 エグチ, ヒロシ Eguchi, Hiroshi 江口 エグチ Eguchi 洋 ヒロシ Hiroshi 70452646 山田, 安希子 ヤマダ, アキコ Yamada, Akiko 山田 ヤマダ Yamada 安希子 アキコ Akiko 50314753 工藤, 保誠 クドウ, ヤスセイ Kudo, Yasusei 工藤 クドウ Kudo 保誠 ヤスセイ Yasusei 90746025 岩浅, 亮彦 イワサ, アキヒコ Iwasa, Akihiko 岩浅 イワサ Iwasa 亮彦 アキヒコ Akihiko Enkhmaa, Tserennadmid ホッタ, フミカ ホッタ, フミカ Hotta, Fumika ミタムラ アイザワ, サヤカ ミタムラ アイザワ, サヤカ Mitamura-Aizawa, Sayaka 30287536 三田村, 佳典 ミタムラ, ヨシノリ Mitamura, Yoshinori 三田村 ミタムラ Mitamura 佳典 ヨシノリ Yoshinori 00127854 林, 良夫 ハヤシ, ヨシオ Hayashi, Yoshio 林 ハヤシ Hayashi 良夫 ヨシオ Yoshio 60314879 石丸, 直澄 イシマル, ナオズミ Ishimaru, Naozumi 石丸 イシマル Ishimaru 直澄 ナオズミ Naozumi open access Copyright: ©2014 Arakaki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Topical therapy is effective for dry eye, and its prolonged effects should help in maintaining the quality of life of patients with dry eye. We previously reported that the oral administration of rebamipide (Reb), a mucosal protective agent, had a potent therapeutic effect on autoimmune lesions in a murine model of Sjögren’s syndrome (SS). However, the effects of topical treatment with Reb eyedrops on the ocular lesions in the murine model of SS are unknown. 　 　Methods and Finding: Reb eyedrops were administered to the murine model of SS aged 4–8 weeks four times daily. Inflammatory lesions of the extraorbital and intraorbital lacrimal glands and Harderian gland tissues were histologically evaluated. The direct effects of Reb on the lacrimal glands were analyzed using cultured lacrimal gland cells. Tear secretions of Reb-treated mice were significantly increased compared with those of untreated mice. In addition to the therapeutic effect of Reb treatment on keratoconjunctivitis, severe inflammatory lesions of intraorbital lacrimal gland tissues in this model of SS were resolved. The mRNA expression levels of IL-10 and mucin 5Ac in conjunctival tissues from Reb-treated mice was significantly increased compared with those of control mice. Moreover, lactoferrin production from lacrimal gland cells was restored by Reb treatment. 　Conclusion: Topical Reb administration had an anti-inflammatory effect on the ocular autoimmune lesions in the murine model of SS and a protective effect on the ocular surfaces. PLOS 2014-05-27 eng journal article VoR 278701 https://tokushima-u.repo.nii.ac.jp/records/2004165 https://doi.org/10.1371/journal.pone.0098390 10.1371/journal.pone.0098390 19326203 PLOS ONE 9 5 e98390 https://tokushima-u.repo.nii.ac.jp/record/2004165/files/pone_9_4_e98390.pdf application/pdf 5.6 MB 2017-12-28