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Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells Alkannin inhibits CCL3 and CCL5 production 90346601 細川, 義隆 ホソカワ, ヨシタカ Hosokawa, Yoshitaka 細川 ホソカワ Hosokawa 義隆 ヨシタカ Yoshitaka 50707908 細川, 育子 ホソカワ, イクコ Hosokawa, Ikuko 細川 ホソカワ Hosokawa 育子 イクコ Ikuko シンドウ, サトル シンドウ, サトル Shindo, Satoru オオタ, ヨシヒロ オオタ, ヨシヒロ Ohta, Yoshihiro 90214121 尾崎, 和美 オザキ, カズミ Ozaki, Kazumi 尾崎 オザキ Ozaki 和美 カズミ Kazumi 30173800 松尾, 敬志 マツオ, タカシ Matsuo, Takashi 松尾 マツオ Matsuo 敬志 タカシ Takashi open access © 2016 International Federation for Cell Biology alkannin CCL3 CCL5 NF‐κB periodontal ligament cells Alkannin, which is found in Alkanna tinctoria, a member of the borage family, is used as a food coloring. Alkannin has recently been reported to have certain biological functions, such as anti-microbial and anti-oxidant effects. It is known that CC chemokine receptor (CCR) 5-positive leukocytes contribute to alveolar bone resorption in periodontal lesions. The aim of this study was to examine whether alkannin inhibits the production of CC chemokine ligand (CCL) 3 and CCL5, which are CCR5 ligands, in human periodontal ligament cells (HPDLC). Interleukin (IL)-1β induced CCL3 and CCL5 production in HPDLC. Alkannin inhibited IL-1β-mediated CCL3 and CCL5 production in HPDLC in a dose-dependent manner. Moreover, we revealed that alkannin suppressed inhibitor of kappa B-α degradation in IL-1β-stimulated HPDLC. In addition, a nuclear factor (NF)-κB inhibitor significantly inhibited CCL3 and CCL5 production in IL-1β-stimulated HPDLC. These results demonstrate that alkannin inhibits CCR5 ligand production in IL-1β-stimulated HPDLC by attenuating the NF-κB signaling pathway. International Federation for Cell Biology Wiley 2016-10-24 eng journal article AM 324808 https://tokushima-u.repo.nii.ac.jp/records/2005960 https://doi.org/10.1002/cbin.10692 10.1002/cbin.10692 10656995 10958355 AA10882014 AA11544414 Cell Biology International 40 12 1380 1385 https://tokushima-u.repo.nii.ac.jp/record/2005960/files/cbin_40_12_1380.pdf application/pdf 342 KB 2018-12-13