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Melatonin Inhibits CXCL10 and MMP-1 Production in IL-1β-Stimulated Human Periodontal Ligament Cells Melatonin inhibits CXCL10 and MMP-1 production 50707908 細川, 育子 ホソカワ, イクコ Hosokawa, Ikuko 細川 ホソカワ Hosokawa 育子 イクコ Ikuko 90346601 細川, 義隆 ホソカワ, ヨシタカ Hosokawa, Yoshitaka 細川 ホソカワ Hosokawa 義隆 ヨシタカ Yoshitaka シンドウ, サトル シンドウ, サトル Shindo, Satoru 90214121 尾崎, 和美 オザキ, カズミ Ozaki, Kazumi 尾崎 オザキ Ozaki 和美 カズミ Kazumi 30173800 松尾, 敬志 マツオ, タカシ Matsuo, Takashi 松尾 マツオ Matsuo 敬志 タカシ Takashi open access melatonin CXCL10 MMP-1 periodontal ligament cells Melatonin is a hormone that is mainly secreted by the pineal gland and exhibits a wide spectrum of activities, including antioxidant functions. Melatonin has been detected in gingival crevicular fluid. However, the role of melatonin in periodontal tissue is still uncertain. The aim of this study was to examine the effects of melatonin on inflammatory mediator expression in human periodontal ligament cells (HPDLC). Interleukin (IL)-1β induced CXC chemokine ligand (CXCL)10, matrix metalloproteinase (MMP)-1, and tissue inhibitors of metalloproteinase (TIMP)-1 production in HPDLC. Melatonin decreased CXCL10 and MMP-1 production and increased TIMP-1 production in IL-1β-stimulated HPDLC. Western blot analysis showed that melatonin inhibited p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK) phosphorylation, and IκB-α degradation and phosphorylation in IL-1β-stimulated HPDLC. These results suggest that melatonin might inhibit Th1 cell migration by reducing CXCL10 production. Moreover, melatonin might inhibit soft tissue destruction by decreasing MMP-1 production in periodontal lesions. Springer 2016-06-06 eng journal article AM 314800 https://tokushima-u.repo.nii.ac.jp/records/2005963 https://doi.org/10.1007/s10753-016-0386-3 10.1007/s10753-016-0386-3 03603997 15732576 AA00673765 AA12117940 Inflammation 39 4 1520 1526 https://tokushima-u.repo.nii.ac.jp/record/2005963/files/inflammation_39_4_1520.pdf application/pdf 442 KB 2018-12-13