2026-03-15T20:50:39Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02006954 2025-06-30T02:34:18Z 1713853213384:1713853296295:1716267876683:1716268551628

Pulmonary Artery Wall Thickness Assessed by Optical Coherence Tomography Correlates With Pulmonary Hemodynamics in Children With Congenital Heart Disease 先天性心疾患の小児における光干渉断層撮影法を用いた肺動脈壁厚と肺循環動態の関連についての検討 PA Thickening on OCT in Children With CHD 本間, 友佳子 ホンマ, ユカコ Honma, Yukako 本間 ホンマ Honma 友佳子 ユカコ Yukako 20403686 早渕, 康信 ハヤブチ, ヤスノブ Hayabuchi, Yasunobu 早渕 ハヤブチ Hayabuchi 康信 ヤスノブ Yasunobu オノ, アケミ オノ, アケミ Ono, Akemi 00224337 香美, 祥二 カガミ, ショウジ Kagami, Shoji 香美 カガミ Kagami 祥二 ショウジ Shoji open access Children Congenital heart disease Optical coherence tomography Pulmonary arterial hypertension Background: Pulmonary arterial (PA) wall thickening evaluated by optical coherence tomography (OCT) has been reported in adults with PA hypertension. The purpose of this study was to evaluate the feasibility of OCT for preoperative assessment of the PA wall in children with congenital heart disease (CHD). Methods and Results: Participants comprised 39 patients with ventricular septal defect, atrial septal defect, or patent ductus arteriosus. Attempts were made to evaluate vessels of various diameters using OCT. Clearly observed vessels that were optimal for evaluation were selected and classified into 4 subgroups by diameter of the lumen. Optimal depiction was obtained in 80 of 156 vessels in total, and 25 (64.1%), 34 (87.1%), 17 (43.6%), and 4 vessels (10.3%) in each of the 1.0–<2.0 mm, 2.0–<3.0 mm, 3.0–<4.0 mm, and 4.0–5.0 mm subgroups, respectively. Arterial walls in the 2.0–<3.0 mm subgroup were the most frequently delineated, and wall thickness correlated significantly with mean PA pressure, pulmonary vascular resistance index, pulmonary-to-systemic flow ratio, and PA capacitance index (r=0.56, 0.52, 0.37, and −0.49, respectively). The 3-layered appearance was delineated in 29 of 80 vessels (36.2%). This feature had no significant correlation with pulmonary hemodynamics. Conclusions: OCT represents a promising tool for evaluating the PA wall in children with CHD. The Japanese Circulation Society 2018-08-24 eng doctoral thesis NA 351112 https://tokushima-u.repo.nii.ac.jp/records/2006954 https://doi.org/10.1253/circj.CJ-18-0379 10.1253/circj.CJ-18-0379 13469843 13474820 AA11591968 Circulation Journal 82 9 2350 2357 甲医第1484号 博士（医学） 2021-03-23 徳島大学 https://tokushima-u.repo.nii.ac.jp/record/2006954/files/k3498_abstract_review.pdf application/pdf 270 KB 2021-04-15 https://tokushima-u.repo.nii.ac.jp/record/2006954/files/k3498_fulltext.pdf application/pdf 1.97 MB 2021-04-15