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oai:tokushima-u.repo.nii.ac.jp:02008600 2025-04-28T07:15:14Z 1713853213384:1713853296295:1716267876683:1716268551628

Urinary adiponectin excretion is an early predictive marker of the decline of the renal function in patients with diabetes mellitus 尿中アディポネクチン排泄は糖尿病患者における腎機能低下の早期予測指標である。 Urinary adiponectin in DKD 石津, 将 イシヅ, マサシ Ishizu, Masashi 石津 イシヅ Ishizu 将 マサシ Masashi 80611772 森, 博康 モリ, ヒロヤス Mori, Hiroyasu 森 モリ Mori 博康 ヒロヤス Hiroyasu オオイシ, マミ オオイシ, マミ Ohishi, Mami 70571412 黒田, 暁生 クロダ, アキオ Kuroda, Akio 黒田 クロダ Kuroda 暁生 アキオ Akio アケヒ, ユウコ アケヒ, ユウコ Akehi, Yuko 40510904 吉田, 守美子 ヨシダ, スミコ Yoshida, Sumiko 吉田 ヨシダ Yoshida 守美子 スミコ Sumiko 70372711 粟飯原, 賢一 アイハラ, ケンイチ Aihara, Ken-ichi 粟飯原 アイハラ Aihara 賢一 ケンイチ Ken-ichi アイバ, モトヒロ アイバ, モトヒロ Aiba, Motohiro カワノ, トモハル カワノ, トモハル Kawano, Tomoharu 橋田, 誠一 ハシダ, セイイチ Hashida, Seiichi 60362737 松久, 宗英 マツヒサ, ムネヒデ Matsuhisa, Munehide 松久 マツヒサ Matsuhisa 宗英 ムネヒデ Munehide open access © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. diabetes kidney disease urinary adiponectin estimated glomerular filtration rate Aims: Since diabetes-associated kidney complication changes from diabetic nephropathy to diabetic kidney disease (DKD), more suitable biomarkers than urinary albumin are required. It has been hypothesized that urinary adiponectin (u-ADPN) is associated with the progression of DKD. We therefore evaluated the effectiveness of u-ADPN in predicting the decline of the renal function in patients with diabetes prior to end-stage renal disease. Methods: An ultrasensitive immune complex transfer enzyme immunoassay (ICT-EIA) was used to measure total and high molecular weight (HMW) adiponectin separately. We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (ΔeGFR). Results: This 2-year prospective observational study included 201 patients with diabetes. These patients were divided into three groups according to their ΔeGFR: ≤-10 ml/min/1.73m2, >-10 and ≤0 ml/min/1.73m2, and >0 ml/min/1.73m2. Jonckheere-Terpstra test showed that lower ΔeGFR was associated with higher u-HMW-ADPN (p = 0.045). In logistic regression analysis, u-HMW-ADPN was associated with ΔeGFR after adjusted age, sex, and basal eGFR. Conclusion: Urinary HMW-ADPN could predict a declining renal function in patients with diabetes. Elsevier 2021-01-07 eng doctoral thesis NA 373630 https://tokushima-u.repo.nii.ac.jp/records/2008600 https://doi.org/10.1016/j.jdiacomp.2021.107848 10.1016/j.jdiacomp.2021.107848 10568727 AA10843748 AA11531864 Journal of Diabetes and its Complications 35 4 107848 甲医第1489号 博士（医学） 2021-03-23 徳島大学 https://tokushima-u.repo.nii.ac.jp/record/2008600/files/k3503_abstract_review.pdf application/pdf 305 KB 2021-06-15 https://tokushima-u.repo.nii.ac.jp/record/2008600/files/k3503_fulltext.pdf application/pdf 994 KB 2021-06-15