2026-03-05T08:30:58Z
https://tokushima-u.repo.nii.ac.jp/oai
oai:tokushima-u.repo.nii.ac.jp:02009073
2025-04-28T07:32:31Z
1713853213384:1713853296295:1716267878536:1716268700025
Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation
ノビレチンは17型ヘルパーT細胞の分化調節により、実験的自己免疫性脳脊髄炎の発症を抑制する
90803536
中本, 晶子
ナカモト, アキコ
Nakamoto, Akiko
中本
ナカモト
Nakamoto
晶子
アキコ
Akiko
ヒラバヤシ, ユウワ
ヒラバヤシ, ユウワ
Hirabayashi, Yuwa
アンザキ, チエリ
アンザキ, チエリ
Anzaki, Chieri
40722533
中本, 真理子
ナカモト, マリコ
Nakamoto, Mariko
中本
ナカモト
Nakamoto
真理子
マリコ
Mariko
10512121
首藤, 恵泉
シュトウ, エミ
Shuto, Emi
首藤
シュトウ
Shuto
恵泉
エミ
Emi
40274196
酒井, 徹
サカイ, トオル
Sakai, Tohru
酒井
サカイ
Sakai
徹
トオル
Tohru
open access
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License.
experimental autoimmune encephalomyelitis
nobiletin
polymethoxyflavonoid
Th17 differentiation
IL-17A
polymethoxyflavone
Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin is a dietary polymethoxylated flavonoid found in citrus fruits. In this study, we investigated how nobiletin affects the disease state and immune responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis mice. Nobiletin was administered orally from 14 days before immunization until the end of the experiment, and clinical scores were determined. The production levels of interleukin-17A and interferon-γ were measured in a culture supernatant of splenocytes stimulated with myelin oligodendrocyte glycoprotein. In addition, flow cytometric analysis was performed to examine the effect of nobiletin on T cell differentiation in vitro. Administration of nobiletin significantly decreased the clinical score and interleukin-17A production in splenocytes. Furthermore, in vitro analysis showed that nobiletin significantly suppressed Th17 cell differentiation and interleukin-17A production in a dose-dependent manner. The results suggest that nobiletin attenuates experimental autoimmune encephalomyelitis severity through modulation of Th17 cell differentiation.
Society for Free Radical Research Japan
2021-09-01
eng
doctoral thesis
NA
382896
https://tokushima-u.repo.nii.ac.jp/records/2009073
https://doi.org/10.3164/jcbn.20-178
10.3164/jcbn.20-178
09120009
18805086
AA10710201
Journal of Clinical Biochemistry and Nutrition
69
2
145
150
乙栄第96号
博士（栄養学）
2021-07-29
徳島大学
https://tokushima-u.repo.nii.ac.jp/record/2009073/files/o2117_abstract_review.pdf
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2021-08-05
https://tokushima-u.repo.nii.ac.jp/record/2009073/files/o2117_fulltext.pdf
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345 KB
2021-09-01