2026-03-10T03:38:21Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02009463 2025-08-27T04:02:44Z 1713853213384:1713853295607

Long-Term Follow-Up of 12 Patients Treated with Bilateral Pallidal Stimulation for Tardive Dystonia 50868586 小山, 広士 コヤマ, ヒロシ Koyama, Hiroshi 小山 コヤマ Koyama 広士 ヒロシ Hiroshi 00624355 牟礼, 英生 ムレ, ヒデオ Mure, Hideo 牟礼 ムレ Mure 英生 ヒデオ Hideo 森垣, 龍馬 モリガキ, リョウマ Morigaki, Ryoma 森垣 モリガキ Morigaki 龍馬 リョウマ Ryoma 宮本, 亮介 ミヤモト, リョウスケ Miyamoto, Ryosuke 宮本 ミヤモト Miyamoto 亮介 リョウスケ Ryosuke 三宅, 一央 ミヤケ, カズヒサ Miyake, Kazuhisa 三宅 ミヤケ Miyake 一央 カズヒサ Kazuhisa 松田, 拓 マツダ, タク Matsuda, Taku 松田 マツダ Matsuda 拓 タク Taku 藤田, 浩司 フジタ, コウジ Fujita, Kouji 藤田 フジタ Fujita 浩司 コウジ Kouji 和泉, 唯信 イズミ, ユイシン Izumi, Yuishin 和泉 イズミ Izumi 唯信 ユイシン Yuishin 00214304 梶, 龍兒 カジ, リュウジ Kaji, Ryuji 梶 カジ Kaji 龍兒 リュウジ Ryuji 後藤, 惠 ゴトウ, サトシ Goto, Satoshi 後藤 ゴトウ Goto 惠 サトシ Satoshi 髙木, 康志 タカギ, ヤスシ Takagi, Yasushi 髙木 タカギ Takagi 康志 ヤスシ Yasushi open access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). tardive dystonia deep brain stimulation globus pallidus internus long-term follow-up Tardive dystonia (TD) is a side effect of prolonged dopamine receptor antagonist intake. TD can be a chronic disabling movement disorder despite medical treatment. We previously demonstrated successful outcomes in six patients with TD using deep brain stimulation (DBS); however, more patients are needed to better understand the efficacy of DBS for treating TD. We assessed the outcomes of 12 patients with TD who underwent globus pallidus internus (GPi) DBS by extending the follow-up period of previously reported patients and enrolling six additional patients. All patients were refractory to pharmacotherapy and were referred for surgical intervention by movement disorder neurologists. In all patients, DBS electrodes were implanted bilaterally within the GPi under general anesthesia. The mean ages at TD onset and surgery were 39.2 ± 12.3 years and 44.6 ± 12.3 years, respectively. The Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS) performed the preoperative and postoperative evaluations. The average BFMDRS improvement rate at 1 month postoperatively was 75.6 ± 27.6% (p < 0.001). Ten patients were assessed in the long term (78.0 ± 50.4 months after surgery), and the long-term BFMDRS improvement was 78.0 ± 20.4%. Two patients responded poorly to DBS. Both had a longer duration from TD onset to surgery and older age at surgery. A cognitive and psychiatric decline was observed in the oldest patients, while no such decline ware observed in the younger patients. In most patients with TD, GPi-DBS could be a beneficial therapeutic option for long-term relief of TD. MDPI 2021-05-24 eng journal article VoR 377488 https://tokushima-u.repo.nii.ac.jp/records/2009463 https://doi.org/10.3390/life11060477 10.3390/life11060477 20751729 Life 11 6 477 https://tokushima-u.repo.nii.ac.jp/record/2009463/files/life_11_6_477.pdf application/pdf 1.55 MB 2022-01-20