2026-03-05T08:36:04Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02011103 2025-04-28T06:02:38Z 1713829974766:1713854681789:1716364512866:1716365092658 1713853213384:1713853295607

Effects of polymethoxyflavonoids on T helper 17 cell differentiation in vitro and in vivo Polymethoxyflavonids and T helper 17 cells 90803536 中本, 晶子 ナカモト, アキコ Nakamoto, Akiko 中本 ナカモト Nakamoto 晶子 アキコ Akiko ヒラバヤシ, ユウワ ヒラバヤシ, ユウワ Hirabayashi, Yuwa アンザキ, チエリ アンザキ, チエリ Anzaki, Chieri 40722533 中本, 真理子 ナカモト, マリコ Nakamoto, Mariko 中本 ナカモト Nakamoto 真理子 マリコ Mariko 10512121 首藤, 恵泉 シュトウ, エミ Shuto, Emi 首藤 シュトウ Shuto 恵泉 エミ Emi ニイ, ヨシタカ ニイ, ヨシタカ Nii, Yoshitaka 40274196 酒井, 徹 サカイ, トオル Sakai, Tohru 酒井 サカイ Sakai 徹 トオル Tohru open access polymethoxyflavonoids nobiletin sudachitin T helper 17 cell IL-17A We examined the effects of polymethoxyflavonoids (PMFs) on T helper (Th) 17 cell differentiation in vitro and in vivo. Five different PMFs including nobiletin (NOB), sudachitin (SUD), demethoxysudachitin, heptamethoxyflavone and natsudaidain were used for the in vitro study, and effects of those flavonoids on Th17 responses were investigated. NOB and heptamethoxyflavone significantly suppressed the proliferation response, but SUD, demethoxysudachitin and natsudaidain did not suppress the proliferation response. All of the five flavonoids decreased IL-17A production. Mice with experimentally induced autoimmune encephalomyelitis were used as an in vivo Th17 differentiation model. We focused on two flavonoids, NOB and SUD, and examined the effects of those flavonoids. NOB significantly suppressed Th17 cell proliferation and cytokine responses, but SUD only decreased proliferation responses. The results suggest that the suppressive effect of NOB on Th17 response in vivo is stronger than that of SUD. Tokushima University Faculty of Medicine 2023-02 eng journal article VoR 398463 https://tokushima-u.repo.nii.ac.jp/records/2011103 https://doi.org/10.2152/jmi.70.166 10.2152/jmi.70.166 13496867 13431420 AA11166929 The Journal of Medical Investigation 70 1-2 166 170 https://tokushima-u.repo.nii.ac.jp/record/2011103/files/jmi_70_1-2_166.pdf application/pdf 906 KB 2023-07-06