2026-03-05T08:50:54Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02002883 2025-04-28T06:32:49Z 1713853213384:1713853295607

YKL-40 secreted from adipose tissue inhibits degradation of type I collagen 10350399 岩田, 武男 イワタ, タケオ Iwata, Takeo 岩田 イワタ Iwata 武男 タケオ Takeo クワジマ, マサミチ クワジマ, マサミチ Kuwajima, Masamichi スケノ, アキコ スケノ, アキコ Sukeno, Akiko 60314879 石丸, 直澄 イシマル, ナオズミ Ishimaru, Naozumi 石丸 イシマル Ishimaru 直澄 ナオズミ Naozumi 00127854 林, 良夫 ハヤシ, ヨシオ Hayashi, Yoshio 林 ハヤシ Hayashi 良夫 ヨシオ Yoshio Wabitsch, Martin 80254746 水澤, 典子 ミズサワ, ノリコ Mizusawa, Noriko 水澤 ミズサワ Mizusawa 典子 ノリコ Noriko 60134227 板倉, 光夫 イタクラ, ミツオ Itakura, Mitsuo 板倉 イタクラ Itakura 光夫 ミツオ Mitsuo 90201863 吉本, 勝彦 ヨシモト, カツヒコ Yoshimoto, Katsuhiko 吉本 ヨシモト Yoshimoto 勝彦 カツヒコ Katsuhiko open access © 2009 Elsevier Inc. All rights reserved.© 2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license YKL-40 MMP-1 type I collagen adipose tissue macrophage preadipocyte Obesity is considered a chronic low-grade inflammatory status and the stromal vascular fraction (SVF) cells of adipose tissue (AT) are considered a source of inflammation-related molecules. We identified YKL-40 as a major protein secreted from SVF cells in human visceral AT. YKL-40 expression levels in SVF cells from visceral AT were higher than in those from subcutaneous AT. Immunofluorescence staining revealed that YKL-40 was exclusively expressed in macrophages among SVF cells. YKL-40 purified from SVF cells inhibited the degradation of type I collagen, a major extracellular matrix of AT, by matrix metalloproteinase (MMP)-1 and increased rate of fibril formation of type I collagen. The expression of MMP-1 in preadipocytes and macrophages was enhanced by interaction between these cells. These results suggest that macrophage/preadipocyte interaction enhances degradation of type I collagen in AT, meanwhile, YKL-40 secreted from macrophages infiltrating into AT inhibits the type I collagen degradation. 2009-10-23 eng journal article AM 210920 https://tokushima-u.repo.nii.ac.jp/records/2002883 http://www.sciencedirect.com/science/article/pii/S0006291X09015770 10.1016/j.bbrc.2009.08.024 0006291X AA00564395 Biochemical and Biophysical Research Communications 388 3 511 516 https://tokushima-u.repo.nii.ac.jp/record/2002883/files/LID201602262002.pdf application/pdf 1.03 MB 2016-02-29