2026-03-05T07:31:33Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02003314 2025-04-28T07:26:22Z 1713853213384:1713853296295:1716267877313:1716268556148

Genipin inhibits MMP-1 and MMP-3 release from TNF-α-stimulated human periodontal ligament cells genipinはTNF-αが誘導するヒト歯根膜細胞のMMP-1およびMMP-3産生を抑制する 進藤, 智 シンドウ, サトル Shindo, Satoru 90346601 細川, 義隆 ホソカワ, ヨシタカ Hosokawa, Yoshitaka 細川 ホソカワ Hosokawa 義隆 ヨシタカ Yoshitaka 50707908 細川, 育子 ホソカワ, イクコ Hosokawa, Ikuko 細川 ホソカワ Hosokawa 育子 イクコ Ikuko 90214121 尾崎, 和美 オザキ, カズミ Ozaki, Kazumi 尾崎 オザキ Ozaki 和美 カズミ Kazumi 30173800 松尾, 敬志 マツオ, タカシ Matsuo, Takashi 松尾 マツオ Matsuo 敬志 タカシ Takashi open access Genipin MMP AMPK MAPKs Periodontal ligament cells Genipin, the aglycon of geniposide found in gardenia fruit has long been considered for treatment of inflammatory diseases in traditional oriental medicine. Genipin has recently been reported to have some pharmacological functions, such as antimicrobial, antitumor, and anti-inflammatory effects. The aim of this study was to examine whether genipin could modify matrix metalloproteinase (MMP)-1 and MMP-3, which are related to the destruction of periodontal tissues in periodontal lesion, expression in tumor necrosis factor (TNF)-a-stimulated human periodontal ligament cells (HPDLCs). Genipin prevented TNF-a- mediated MMP-1 and MMP-3 productions in HPDLCs. Moreover, genipin could suppress not only extracellular signal-regulated kinase (ERK) and Jun-N-terminal kinase (JNK) phosphorylations but also AMP-activated protein kinase (AMPK) phosphorylation in TNF-a-stimulated HPDLCs. Inhibitors of ERK and AMPK could inhibit both MMP-1 and MMP-3 productions. Moreover, we revealed the ERK inhibitor suppressed AMPK phosphorylation in TNF-a-stimulated HPDLCs. These data provide a new mechanism through which genipin could be used for the treatment of periodontal disease to prevent MMPs expression in periodontal lesion. Elsevier B.V. Société Française de Biochimie et Biologie Moléculaire (SFBBM). 2014-10-18 eng doctoral thesis NA 289078 https://tokushima-u.repo.nii.ac.jp/records/2003314 http://doi.org/10.1016/j.biochi.2014.10.008 10.1016/j.biochi.2014.10.008 03009084 AA11522535 AA00564792 Biochimie 107 B 391 395 甲口第425号 博士（歯学） 2017-03-23 徳島大学 https://tokushima-u.repo.nii.ac.jp/record/2003314/files/LID201704261014.pdf application/pdf 43.6 KB 2017-04-26 https://tokushima-u.repo.nii.ac.jp/record/2003314/files/LID201704261015.pdf application/pdf 37.6 KB 2017-04-26 https://tokushima-u.repo.nii.ac.jp/record/2003314/files/LID201704261016.pdf application/pdf 800 KB 2017-04-26