2026-03-09T08:41:39Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02003993 2025-04-28T06:01:32Z 1713829974766:1713854681789:1716364518663:1716421310005 1713853213384:1713853295607

Expression analysis of a mouse orthologue of HSFY, a candidate for the azoospermic factor on the human Y chromosome キノシタ, ケイゴ キノシタ, ケイゴ Kinoshita, Keigo 新家, 利一 シンカ, トシカツ Shinka, Toshikatsu 10363160 佐藤, 陽一 サトウ, ヨウイチ Sato, Youichi 佐藤 サトウ Sato 陽一 ヨウイチ Youichi クラハシ, ヒロキ クラハシ, ヒロキ Kurahashi, Hiroki コウワ, ヒロエ コウワ, ヒロエ Kowa, Hiroe Chen, Gang 梅野, 真由美 ウメノ, マユミ Umeno, Mayumi 樋田, 一徳 トイダ, カズノリ Toida, Kazunori キヨカゲ, エミ キヨカゲ, エミ Kiyokage, Emi ナカノ, タクロウ ナカノ, タクロウ Nakano, Takuro 伊東, 進 イトウ, ススム Ito, Susumu 伊東 イトウ Ito 進 ススム Susumu 中堀, 豊 ナカホリ, ユタカ Nakahori, Yutaka open access HSFY mHSFYL HSF Y chromosome spermatogenesis Heat shock transcription factor on Y (HSFY) is located in one of three candidate regions for azoospermic factor (AZF), AZFb on the Y chromosome. We and others have already revealed that some azoospermic males are missing the regions of the Y chromosome including HSFY. Previously, we showed that murine HSFY-like sequence〔mHSFYL(RikencDNA4933413G11Rik)〕, which is the mouse orthologue of HSFY, is exclusively expressed in testis. The sequences encoding the presumed DNA-binding domain in HSFY and mHSFYL were found in other mammals such as dogs, cows and chickens. To elucidate mHSFYL expression in the testes in detail, we carried out in situ hybridization. mHSFYL was predominantly expressed in round spermatids. Furthermore, we clarified the intracellular distribution of mHSFYL inCOS1 cells with HA- or GFP-tagged proteins. Both HA-mHSFYL and GFP-mHSFYL were located in the nucleus. Our results suggest that HSFY/mHSFYL may have evolutionarily conserved functions for spermatogenesis. 2006-02 eng journal article VoR 160586 https://tokushima-u.repo.nii.ac.jp/records/2003993 https://doi.org/10.2152/jmi.53.117 10.2152/jmi.53.117 13431420 AA11166929 The journal of medical investigation : JMI 53 1-2 117 122 https://tokushima-u.repo.nii.ac.jp/record/2003993/files/jmi_53_1-2_117.pdf application/pdf 263 KB 2017-12-07