2026-03-05T08:51:47Z
https://tokushima-u.repo.nii.ac.jp/oai
oai:tokushima-u.repo.nii.ac.jp:02005073
2025-04-28T06:50:41Z
1713853213384:1713853295607
Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker
ヤマモト, ジュン
ヤマモト, ジュン
Yamamoto, Jun
マエダ, ナミ
マエダ, ナミ
Maeda, Nami
コミヤ, チアキ
コミヤ, チアキ
Komiya, Chiaki
タナカ, トモヒロ
タナカ, トモヒロ
Tanaka, Tomohiro
00813891
傳田, 将也
デンダ, マサヤ
Denda, Masaya
傳田
デンダ
Denda
将也
マサヤ
Masaya
エビスノ, コウジ
エビスノ, コウジ
Ebisuno, Koji
ノムラ, ワタル
ノムラ, ワタル
Nomura, Wataru
タマムラ, ヒロカズ
タマムラ, ヒロカズ
Tamamura, Hirokazu
10363160
佐藤, 陽一
サトウ, ヨウイチ
Sato, Youichi
佐藤
サトウ
Sato
陽一
ヨウイチ
Youichi
30122253
山内, あい子
ヤマウチ, アイコ
Yamauchi, Aiko
山内
ヤマウチ
Yamauchi
あい子
アイコ
Aiko
10423394
重永, 章
シゲナガ, アキラ
Shigenaga, Akira
重永
シゲナガ
Shigenaga
章
アキラ
Akira
20201973
大髙, 章
オオタカ, アキラ
Otaka, Akira
大髙
オオタカ
Otaka
章
アキラ
Akira
open access
© 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Cleavable linker
Fluoride-responsive
Traceable linker
Stimulus-responsive amino acid
A fluoride-responsive (FR) amino acid that induces amide bond cleavage upon the addition of a fluoride was developed, and it was applied to a FR traceable linker. By the use of an alkyne-containing peptide as a model of an alkynylatd target protein of a bioactive compound, introduction of the FR traceable linker onto the peptide was achieved. Subsequent fluoride induced cleavage of the linker followed by labeling of the released peptide derivative was also conducted to examine the potential applicability of the FR traceable linker to the enrichment and labeling of alkynylated target molecules.
Elsevier Ltd.
2014-06-06
eng
journal article
AM
278985
https://tokushima-u.repo.nii.ac.jp/records/2005073
https://doi.org/10.1016/j.tet.2014.05.110
10.1016/j.tet.2014.05.110
00404020
AA00861787
AA11539786
Tetrahedron
70
34
5122
5127
https://tokushima-u.repo.nii.ac.jp/record/2005073/files/tet_70_34_5122.pdf
application/pdf
827 KB
2018-07-27
https://tokushima-u.repo.nii.ac.jp/record/2005073/files/tet_70_34_5122_si.pdf
application/pdf
54.3 KB
2018-07-27