2026-03-15T21:33:18Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02005964 2025-04-28T06:24:02Z 1713853213384:1713853295607

Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells Gomisin N inhibits inflammatory cytokine production. 90346601 細川, 義隆 ホソカワ, ヨシタカ Hosokawa, Yoshitaka 細川 ホソカワ Hosokawa 義隆 ヨシタカ Yoshitaka 50707908 細川, 育子 ホソカワ, イクコ Hosokawa, Ikuko 細川 ホソカワ Hosokawa 育子 イクコ Ikuko シンドウ, サトル シンドウ, サトル Shindo, Satoru 90214121 尾崎, 和美 オザキ, カズミ Ozaki, Kazumi 尾崎 オザキ Ozaki 和美 カズミ Kazumi 30173800 松尾, 敬志 マツオ, タカシ Matsuo, Takashi 松尾 マツオ Matsuo 敬志 タカシ Takashi open access gomisin N inflammatory cytokine MAPKs periodontal ligament cells Gomisin N, which is a lignan isolated from Schisandra chinensis, has some pharmacological effects. However, the anti-inflammatory effects of gomisin N on periodontal disease are uncertain. The aim of this study was to examine the effect of gomisin N on inflammatory mediator production in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLC). Gomisin N inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 2, and CCL20 production in TNF-α-stimulated HPDLC in a dose-dependent manner. Moreover, we revealed that gomisin N could suppress extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase (JNK) phosphorylation in TNF-α-stimulated HPDLC though protein kinase B (Akt) phosphorylation was not suppressed by gomisin N treatment. In summary, gomisin N might exert antiinflammatory effects by attenuating cytokine production in periodontal ligament cells via inhibiting the TNF-α-stimulated ERK and JNK pathways activation. Springer 2016-11-28 eng journal article AM 324807 https://tokushima-u.repo.nii.ac.jp/records/2005964 https://doi.org/10.1007/s10753-016-0482-4 10.1007/s10753-016-0482-4 03603997 15732576 AA00673765 AA12117940 Inflammation 40 2 360 365 https://tokushima-u.repo.nii.ac.jp/record/2005964/files/inflammation_40_2_360.pdf application/pdf 471 KB 2018-12-13