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oai:tokushima-u.repo.nii.ac.jp:02005965 2025-04-28T06:24:02Z 1713853213384:1713853295607

IL-29 Enhances CXCL10 Production in TNF-α-stimulated Human Oral Epithelial Cells IL-29 enhances CXCL10 production 90346601 細川, 義隆 ホソカワ, ヨシタカ Hosokawa, Yoshitaka 細川 ホソカワ Hosokawa 義隆 ヨシタカ Yoshitaka 50707908 細川, 育子 ホソカワ, イクコ Hosokawa, Ikuko 細川 ホソカワ Hosokawa 育子 イクコ Ikuko シンドウ, サトル シンドウ, サトル Shindo, Satoru 90214121 尾崎, 和美 オザキ, カズミ Ozaki, Kazumi 尾崎 オザキ Ozaki 和美 カズミ Kazumi 30173800 松尾, 敬志 マツオ, タカシ Matsuo, Takashi 松尾 マツオ Matsuo 敬志 タカシ Takashi open access CXCL10 IL-29 oral epithelial cells Interleukin-29 (IL-29) is a cytokine belonging to the type III interferon family. It was recently detected in the gingival crevicular fluid of periodontitis patients. However, the role of IL-29 in the pathogenesis of periodontal disease remains unknown. The aim of this study was to examine the effects of IL-29 on C-X-C motif chemokine ligand 10 (CXCL10) production in human oral epithelial cells. We measured CXCL10 production in TR146 cells, which is a human oral epithelial cell line, using an enzyme-linked immunosorbent assay. We used Western blot analysis to detect IL-29 receptor expression and the phosphorylation levels of signal transduction molecules, including p38 mitogen-activated protein kinases (MAPK), signal transducer and activator of transcription 3 (STAT3), and nuclear factor (NF)-κB p65, in the TR146 cells. The TR146 cells expressed the IL-29 receptor. IL-29 induced CXCL10 production in the TR146 cells. IL-29 significantly enhanced CXCL10 production in tumor necrosis factor (TNF)-α-stimulated TR146 cells. The p38 MAPK, STAT3, and NF-κB pathways were found to be related to the IL-29-induced enhancement of CXCL10 production in TNF-α-stimulated TR146 cells. IL-29 promotes T helper 1 cell accumulation in periodontal lesions by inducing CXCL10 production in oral epithelial cells. Taylor & Francis 2017-07-28 eng journal article AM 326882 https://tokushima-u.repo.nii.ac.jp/records/2005965 https://doi.org/10.1080/08820139.2017.1336176 10.1080/08820139.2017.1336176 08820139 15324311 AA10519794 Immunological Investigations : A Journal of Molecular and Cellular Immunology 46 6 615 624 https://tokushima-u.repo.nii.ac.jp/record/2005965/files/imminv_ 46_6_ 615.pdf application/pdf 382 KB 2018-12-13