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oai:tokushima-u.repo.nii.ac.jp:02007453 2025-04-28T05:00:54Z 1713853213384:1713853295607

Considerations in hiPSC-derived cartilage for articular cartilage repair ヤマシタ, アキヒロ ヤマシタ, アキヒロ Yamashita, Akihiro 玉村, 禎宏 タマムラ, ヨシヒロ Tamamura, Yoshihiro 玉村 タマムラ Tamamura 禎宏 ヨシヒロ Yoshihiro モリオカ, ミホ モリオカ, ミホ Morioka, Miho Karagiannis, Peter シマ, ノブユキ シマ, ノブユキ Shima, Nobuyuki ツマキ, ノリユキ ツマキ, ノリユキ Tsumaki, Noriyuki open access © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Chondrocytes Articular cartilage Regeneration Induced pluripotent stem cells Transplantation Background: A lack of cell or tissue sources hampers regenerative medicine for articular cartilage damage. Main text: We review and discuss the possible use of pluripotent stem cells as a new source for future clinical use. Human induced pluripotent stem cells (hiPSCs) have several advantages over human embryonic stem cells (hESCs). Methods for the generation of chondrocytes and cartilage from hiPSCs have been developed. To reduce the cost of this regenerative medicine, allogeneic transplantation is preferable. hiPSC-derived cartilage shows low immunogenicity like native cartilage, because the cartilage is avascular and chondrocytes are segregated by the extracellular matrix. In addition, we consider our experience with the aberrant deposition of lipofuscin or melanin on cartilage during the chondrogenic differentiation of hiPSCs. Short conclusion: Cartilage generated from allogeneic hiPSC-derived cartilage can be used to repair articular cartilage damage. BioMed Central Springer Nature 2018-10-04 eng journal article VoR 357059 https://tokushima-u.repo.nii.ac.jp/records/2007453 https://doi.org/10.1186/s41232-018-0075-8 10.1186/s41232-018-0075-8 18808190 Inflammation and Regeneration 38 17 https://tokushima-u.repo.nii.ac.jp/record/2007453/files/ir_38_17.pdf application/pdf 2.46 MB 2020-11-26