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Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice 軽度な慢性ストレスはマウスの睡眠を障害し疼痛感受性を増大させる ダラノン, ジュネル カシニリヨ ダラノン, ジュネル カシニリヨ Dalanon, Junhel Casinillo 00452649 近久, 幸子 チカヒサ, サチコ Chikahisa, Sachiko 近久 チカヒサ Chikahisa 幸子 サチコ Sachiko 70372729 志内, 哲也 シウチ, テツヤ Shiuchi, Tetsuya 志内 シウチ Shiuchi 哲也 テツヤ Tetsuya 70755470 清水, 紀之 シミズ, ノリユキ Shimizu, Noriyuki 清水 シミズ Shimizu 紀之 ノリユキ Noriyuki Chavan, Parimal 40581393 鈴木, 善貴 スズキ, ヨシタカ Suzuki, Yoshitaka 鈴木 スズキ Suzuki 善貴 ヨシタカ Yoshitaka 70304540 大倉, 一夫 オオクラ, カズオ Okura, Kazuo 大倉 オオクラ Okura 一夫 カズオ Kazuo 40206602 勢井, 宏義 セイ, ヒロヨシ Sei, Hiroyoshi 勢井 セイ Sei 宏義 ヒロヨシ Hiroyoshi 90243477 松香, 芳三 マツカ, ヨシゾウ Matsuka, Yoshizo 松香 マツカ Matsuka 芳三 ヨシゾウ Yoshizo open access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Hyperalgesia Predictable chronic mild stress Sleep Slow-wave activity Interleukin-6 Tumor necrosis factor-alpha Even though it has been well documented that stress can lead to the development of sleep disorders and the intensification of pain, their relationships have not been fully understood. The present study was aimed at investigating the effects of predictable chronic mild stress (PCMS) on sleep–wake states and pain threshold, using the PCMS rearing conditions of mesh wire (MW) and water (W) for 21 days. Exposure to PCMS decreased the amount of non-rapid eye movement (NREM) sleep during the dark phase. Moreover, the chronicity of PCMS decreased slow-wave activity (SWA) during NREM sleep in the MW and W groups in both the light and dark phases. Mechanical and aversively hot thermal hyperalgesia were more intensified in the PCMS groups than the control. Higher plasma corticosterone levels were seen in mice subjected to PCMS, whereas TNF-α expression was found higher in the hypothalamus in the W and the trigeminal ganglion in the MW group. The W group had higher expression levels of IL-6 in the thalamus as well. The PCMS paradigm decreased SWA and may have intensified mechanical and thermal hyperalgesia. The current study also suggests that rearing under PCMS may cause impaired sleep quality and heightened pain sensation to painful mechanical and aversively hot thermal stimuli. Springer Nature 2021-07-09 eng doctoral thesis NA 376593 https://tokushima-u.repo.nii.ac.jp/records/2009059 https://doi.org/10.1038/s41598-021-93560-7 10.1038/s41598-021-93560-7 20452322 Scientific Reports 11 14231 甲口第473号 博士（歯学） 2021-09-09 徳島大学 https://tokushima-u.repo.nii.ac.jp/record/2009059/files/k3542_abstract.pdf application/pdf 120 KB 2021-10-06 https://tokushima-u.repo.nii.ac.jp/record/2009059/files/k3542_review.pdf application/pdf 69.9 KB 2021-10-06 https://tokushima-u.repo.nii.ac.jp/record/2009059/files/k3542_fulltext.pdf application/pdf 1.38 MB 2021-10-06