2026-03-15T20:12:03Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02010539 2025-04-28T06:01:39Z 1713853213384:1713853295607

Role of Protein Phosphatase 2A in Osteoblast Differentiation and Function 20380024 岡村, 裕彦 オカムラ, ヒロヒコ Okamura, Hirohiko 岡村 オカムラ Okamura 裕彦 ヒロヒコ Hirohiko 60363157 吉田, 賀弥 ヨシダ, カヤ Yoshida, Kaya 吉田 ヨシダ Yoshida 賀弥 カヤ Kaya 森本, 景之 モリモト, ヒロユキ Morimoto, Hiroyuki 20515986 寺町, 順平 テラマチ, ジュンペイ Teramachi, Jumpei 寺町 テラマチ Teramachi 順平 ジュンペイ Jumpei 落合, 和彦 オチアイ, カズヒコ Ochiai, Kazuhiko 50156379 羽地, 達次 ハネジ, タツジ Haneji, Tatsuji 羽地 ハネジ Haneji 達次 タツジ Tatsuji 山本, 朗仁 ヤマモト, アキヒト Yamamoto, Akihito 山本 ヤマモト Yamamoto 朗仁 アキヒト Akihito open access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). protein phosphatase bone formation osteoblast differentiation osteosarcoma cells osteoclastogenesis adipogenesis The reversible phosphorylation of proteins plays hugely important roles in a variety of cellular processes, such as differentiation, proliferation, and apoptosis. These processes are strictly controlled by protein kinases (phosphorylation) and phosphatases (de-phosphorylation). Here we provide a brief history of the study of protein phosphorylation, including a summary of different types of protein kinases and phosphatases. One of the most physiologically important serine/threonine phosphatases is PP2A. This review provides a description of the phenotypes of various PP2A transgenic mice and further focuses on the known functions of PP2A in bone formation, including its role in osteoblast differentiation and function. A reduction in PP2A promotes bone formation and osteoblast differentiation through the regulation of bone-related transcription factors such as Osterix. Interestingly, downregulation of PP2A also stimulates adipocyte differentiation from undifferentiated mesenchymal cells under the appropriate adipogenic differentiation conditions. In osteoblasts, PP2A is also involved in the ability to control osteoclastogenesis as well as in the proliferation and metastasis of osteosarcoma cells. Thus, PP2A is considered to be a comprehensive factor in controlling the differentiation and function of cells derived from mesenchymal cells such as osteoblasts and adipocytes. MDPI 2017-02-23 eng journal article VoR 323167 https://tokushima-u.repo.nii.ac.jp/records/2010539 https://doi.org/10.3390/jcm6030023 10.3390/jcm6030023 20770383 Journal of Clinical Medicine 6 3 23 https://tokushima-u.repo.nii.ac.jp/record/2010539/files/jcm_6_3_23.pdf application/pdf 851 KB 2022-12-26