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Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker ヤマモト, ジュン ヤマモト, ジュン Yamamoto, Jun マエダ, ナミ マエダ, ナミ Maeda, Nami コミヤ, チアキ コミヤ, チアキ Komiya, Chiaki タナカ, トモヒロ タナカ, トモヒロ Tanaka, Tomohiro 傳田, 将也 1004 デンダ, マサヤ 364585/profile-ja.html Denda, Masaya 00813891 エビスノ, コウジ エビスノ, コウジ Ebisuno, Koji ノムラ, ワタル ノムラ, ワタル Nomura, Wataru タマムラ, ヒロカズ タマムラ, ヒロカズ Tamamura, Hirokazu 佐藤, 陽一 1215 サトウ, ヨウイチ 73845/profile-ja.html Sato, Youichi 10363160 山内, あい子 1147 ヤマウチ, アイコ 60647/profile-ja.html Yamauchi, Aiko 30122253 重永, 章 232 シゲナガ, アキラ 10423394 Shigenaga, Akira 大髙, 章 188 オオタカ, アキラ 121537/profile-ja.html Otaka, Akira 20201973 Cleavable linker Fluoride-responsive Traceable linker Stimulus-responsive amino acid A fluoride-responsive (FR) amino acid that induces amide bond cleavage upon the addition of a fluoride was developed, and it was applied to a FR traceable linker. By the use of an alkyne-containing peptide as a model of an alkynylatd target protein of a bioactive compound, introduction of the FR traceable linker onto the peptide was achieved. Subsequent fluoride induced cleavage of the linker followed by labeling of the released peptide derivative was also conducted to examine the potential applicability of the FR traceable linker to the enrichment and labeling of alkynylated target molecules. journal article Elsevier Ltd. 2014-06-06 AM application/pdf application/pdf Tetrahedron 34 70 5122 5127 00404020 AA00861787 AA11539786 https://tokushima-u.repo.nii.ac.jp/record/2005073/files/tet_70_34_5122.pdf https://tokushima-u.repo.nii.ac.jp/record/2005073/files/tet_70_34_5122_si.pdf https://tokushima-u.repo.nii.ac.jp/records/2005073 eng © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/