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oai:tokushima-u.repo.nii.ac.jp:02005960 2025-04-28T06:24:01Z 1713853213384:1713853295607

Alkannin inhibits CCL3 and CCL5 production Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells 細川, 義隆 1678 ホソカワ, ヨシタカ 60360/profile-ja.html Hosokawa, Yoshitaka 90346601 細川, 育子 622 ホソカワ, イクコ 261400/profile-ja.html Hosokawa, Ikuko 50707908 シンドウ, サトル シンドウ, サトル Shindo, Satoru オオタ, ヨシヒロ オオタ, ヨシヒロ Ohta, Yoshihiro 尾崎, 和美 1705 オザキ, カズミ 60420/profile-ja.html Ozaki, Kazumi 90214121 松尾, 敬志 1653 マツオ, タカシ 60313/profile-ja.html Matsuo, Takashi 30173800 alkannin CCL3 CCL5 NF‐κB periodontal ligament cells Alkannin, which is found in Alkanna tinctoria, a member of the borage family, is used as a food coloring. Alkannin has recently been reported to have certain biological functions, such as anti-microbial and anti-oxidant effects. It is known that CC chemokine receptor (CCR) 5-positive leukocytes contribute to alveolar bone resorption in periodontal lesions. The aim of this study was to examine whether alkannin inhibits the production of CC chemokine ligand (CCL) 3 and CCL5, which are CCR5 ligands, in human periodontal ligament cells (HPDLC). Interleukin (IL)-1β induced CCL3 and CCL5 production in HPDLC. Alkannin inhibited IL-1β-mediated CCL3 and CCL5 production in HPDLC in a dose-dependent manner. Moreover, we revealed that alkannin suppressed inhibitor of kappa B-α degradation in IL-1β-stimulated HPDLC. In addition, a nuclear factor (NF)-κB inhibitor significantly inhibited CCL3 and CCL5 production in IL-1β-stimulated HPDLC. These results demonstrate that alkannin inhibits CCR5 ligand production in IL-1β-stimulated HPDLC by attenuating the NF-κB signaling pathway. journal article International Federation for Cell Biology Wiley 2016-10-24 AM application/pdf Cell Biology International 12 40 1380 1385 10656995 10958355 AA10882014 AA11544414 https://tokushima-u.repo.nii.ac.jp/record/2005960/files/cbin_40_12_1380.pdf https://tokushima-u.repo.nii.ac.jp/records/2005960 eng © 2016 International Federation for Cell Biology