2026-03-15T21:32:13Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02005963 2025-04-28T06:24:03Z 1713853213384:1713853295607

Melatonin inhibits CXCL10 and MMP-1 production Melatonin Inhibits CXCL10 and MMP-1 Production in IL-1β-Stimulated Human Periodontal Ligament Cells 細川, 育子 622 ホソカワ, イクコ 261400/profile-ja.html Hosokawa, Ikuko 50707908 細川, 義隆 1678 ホソカワ, ヨシタカ 60360/profile-ja.html Hosokawa, Yoshitaka 90346601 シンドウ, サトル シンドウ, サトル Shindo, Satoru 尾崎, 和美 1705 オザキ, カズミ 60420/profile-ja.html Ozaki, Kazumi 90214121 松尾, 敬志 1653 マツオ, タカシ 60313/profile-ja.html Matsuo, Takashi 30173800 melatonin CXCL10 MMP-1 periodontal ligament cells Melatonin is a hormone that is mainly secreted by the pineal gland and exhibits a wide spectrum of activities, including antioxidant functions. Melatonin has been detected in gingival crevicular fluid. However, the role of melatonin in periodontal tissue is still uncertain. The aim of this study was to examine the effects of melatonin on inflammatory mediator expression in human periodontal ligament cells (HPDLC). Interleukin (IL)-1β induced CXC chemokine ligand (CXCL)10, matrix metalloproteinase (MMP)-1, and tissue inhibitors of metalloproteinase (TIMP)-1 production in HPDLC. Melatonin decreased CXCL10 and MMP-1 production and increased TIMP-1 production in IL-1β-stimulated HPDLC. Western blot analysis showed that melatonin inhibited p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK) phosphorylation, and IκB-α degradation and phosphorylation in IL-1β-stimulated HPDLC. These results suggest that melatonin might inhibit Th1 cell migration by reducing CXCL10 production. Moreover, melatonin might inhibit soft tissue destruction by decreasing MMP-1 production in periodontal lesions. journal article Springer 2016-06-06 AM application/pdf Inflammation 4 39 1520 1526 03603997 15732576 AA00673765 AA12117940 https://tokushima-u.repo.nii.ac.jp/record/2005963/files/inflammation_39_4_1520.pdf https://tokushima-u.repo.nii.ac.jp/records/2005963 eng