2026-03-15T21:21:25Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02005965 2025-04-28T06:24:02Z 1713853213384:1713853295607

IL-29 enhances CXCL10 production IL-29 Enhances CXCL10 Production in TNF-α-stimulated Human Oral Epithelial Cells 細川, 義隆 1678 ホソカワ, ヨシタカ 60360/profile-ja.html Hosokawa, Yoshitaka 90346601 細川, 育子 622 ホソカワ, イクコ 261400/profile-ja.html Hosokawa, Ikuko 50707908 シンドウ, サトル シンドウ, サトル Shindo, Satoru 尾崎, 和美 1705 オザキ, カズミ 60420/profile-ja.html Ozaki, Kazumi 90214121 松尾, 敬志 1653 マツオ, タカシ 60313/profile-ja.html Matsuo, Takashi 30173800 CXCL10 IL-29 oral epithelial cells Interleukin-29 (IL-29) is a cytokine belonging to the type III interferon family. It was recently detected in the gingival crevicular fluid of periodontitis patients. However, the role of IL-29 in the pathogenesis of periodontal disease remains unknown. The aim of this study was to examine the effects of IL-29 on C-X-C motif chemokine ligand 10 (CXCL10) production in human oral epithelial cells. We measured CXCL10 production in TR146 cells, which is a human oral epithelial cell line, using an enzyme-linked immunosorbent assay. We used Western blot analysis to detect IL-29 receptor expression and the phosphorylation levels of signal transduction molecules, including p38 mitogen-activated protein kinases (MAPK), signal transducer and activator of transcription 3 (STAT3), and nuclear factor (NF)-κB p65, in the TR146 cells. The TR146 cells expressed the IL-29 receptor. IL-29 induced CXCL10 production in the TR146 cells. IL-29 significantly enhanced CXCL10 production in tumor necrosis factor (TNF)-α-stimulated TR146 cells. The p38 MAPK, STAT3, and NF-κB pathways were found to be related to the IL-29-induced enhancement of CXCL10 production in TNF-α-stimulated TR146 cells. IL-29 promotes T helper 1 cell accumulation in periodontal lesions by inducing CXCL10 production in oral epithelial cells. journal article Taylor & Francis 2017-07-28 AM application/pdf Immunological Investigations : A Journal of Molecular and Cellular Immunology 6 46 615 624 08820139 15324311 AA10519794 https://tokushima-u.repo.nii.ac.jp/record/2005965/files/imminv_ 46_6_ 615.pdf https://tokushima-u.repo.nii.ac.jp/records/2005965 eng