2026-03-10T03:43:03Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02008600 2025-04-28T07:15:14Z 1713853213384:1713853296295:1716267876683:1716268551628

尿中アディポネクチン排泄は糖尿病患者における腎機能低下の早期予測指標である。 Urinary adiponectin in DKD Urinary adiponectin excretion is an early predictive marker of the decline of the renal function in patients with diabetes mellitus 石津, 将 1426 イシヅ, マサシ 375080/profile-ja.html Ishizu, Masashi 森, 博康 732 モリ, ヒロヤス 286336/profile-ja.html Mori, Hiroyasu 80611772 オオイシ, マミ オオイシ, マミ Ohishi, Mami 黒田, 暁生 522 クロダ, アキオ 229225/profile-ja.html Kuroda, Akio 70571412 アケヒ, ユウコ アケヒ, ユウコ Akehi, Yuko 吉田, 守美子 518 ヨシダ, スミコ 229104/profile-ja.html Yoshida, Sumiko 40510904 粟飯原, 賢一 1224 アイハラ, ケンイチ 75205/profile-ja.html Aihara, Ken-ichi 70372711 アイバ, モトヒロ アイバ, モトヒロ Aiba, Motohiro カワノ, トモハル カワノ, トモハル Kawano, Tomoharu 橋田, 誠一 ハシダ, セイイチ Hashida, Seiichi 松久, 宗英 415 マツヒサ, ムネヒデ 205776/profile-ja.html Matsuhisa, Munehide 60362737 diabetes kidney disease urinary adiponectin estimated glomerular filtration rate Aims: Since diabetes-associated kidney complication changes from diabetic nephropathy to diabetic kidney disease (DKD), more suitable biomarkers than urinary albumin are required. It has been hypothesized that urinary adiponectin (u-ADPN) is associated with the progression of DKD. We therefore evaluated the effectiveness of u-ADPN in predicting the decline of the renal function in patients with diabetes prior to end-stage renal disease. Methods: An ultrasensitive immune complex transfer enzyme immunoassay (ICT-EIA) was used to measure total and high molecular weight (HMW) adiponectin separately. We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (ΔeGFR). Results: This 2-year prospective observational study included 201 patients with diabetes. These patients were divided into three groups according to their ΔeGFR: ≤-10 ml/min/1.73m2, >-10 and ≤0 ml/min/1.73m2, and >0 ml/min/1.73m2. Jonckheere-Terpstra test showed that lower ΔeGFR was associated with higher u-HMW-ADPN (p = 0.045). In logistic regression analysis, u-HMW-ADPN was associated with ΔeGFR after adjusted age, sex, and basal eGFR. Conclusion: Urinary HMW-ADPN could predict a declining renal function in patients with diabetes. doctoral thesis Elsevier 2021-01-07 NA application/pdf application/pdf Journal of Diabetes and its Complications 4 35 107848 10568727 AA10843748 AA11531864 https://tokushima-u.repo.nii.ac.jp/record/2008600/files/k3503_abstract_review.pdf https://tokushima-u.repo.nii.ac.jp/record/2008600/files/k3503_fulltext.pdf https://tokushima-u.repo.nii.ac.jp/records/2008600 eng © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.