2026-03-05T08:14:59Z https://tokushima-u.repo.nii.ac.jp/oai

oai:tokushima-u.repo.nii.ac.jp:02011103 2025-04-28T06:02:38Z 1713829974766:1713854681789:1716364512866:1716365092658 1713853213384:1713853295607

Polymethoxyflavonids and T helper 17 cells Effects of polymethoxyflavonoids on T helper 17 cell differentiation in vitro and in vivo 中本, 晶子 863 ナカモト, アキコ 323760/profile-ja.html Nakamoto, Akiko 90803536 ヒラバヤシ, ユウワ ヒラバヤシ, ユウワ Hirabayashi, Yuwa アンザキ, チエリ アンザキ, チエリ Anzaki, Chieri 中本, 真理子 782 ナカモト, マリコ 293911/profile-ja.html Nakamoto, Mariko 40722533 首藤, 恵泉 324 シュトウ, エミ 10512121 Shuto, Emi ニイ, ヨシタカ ニイ, ヨシタカ Nii, Yoshitaka 酒井, 徹 1196 サカイ, トオル 60693/profile-ja.html Sakai, Tohru 40274196 polymethoxyflavonoids nobiletin sudachitin T helper 17 cell IL-17A We examined the effects of polymethoxyflavonoids (PMFs) on T helper (Th) 17 cell differentiation in vitro and in vivo. Five different PMFs including nobiletin (NOB), sudachitin (SUD), demethoxysudachitin, heptamethoxyflavone and natsudaidain were used for the in vitro study, and effects of those flavonoids on Th17 responses were investigated. NOB and heptamethoxyflavone significantly suppressed the proliferation response, but SUD, demethoxysudachitin and natsudaidain did not suppress the proliferation response. All of the five flavonoids decreased IL-17A production. Mice with experimentally induced autoimmune encephalomyelitis were used as an in vivo Th17 differentiation model. We focused on two flavonoids, NOB and SUD, and examined the effects of those flavonoids. NOB significantly suppressed Th17 cell proliferation and cytokine responses, but SUD only decreased proliferation responses. The results suggest that the suppressive effect of NOB on Th17 response in vivo is stronger than that of SUD. journal article Tokushima University Faculty of Medicine 2023-02 VoR application/pdf The Journal of Medical Investigation 1-2 70 166 170 13496867 13431420 AA11166929 https://tokushima-u.repo.nii.ac.jp/record/2011103/files/jmi_70_1-2_166.pdf https://tokushima-u.repo.nii.ac.jp/records/2011103 eng