{"created":"2024-09-03T23:46:52.549090+00:00","id":2000088,"links":{},"metadata":{"_buckets":{"deposit":"27396427-9bd7-432f-bd65-a09a46e3f906"},"_deposit":{"created_by":50,"id":"2000088","owner":"50","owners":[50],"pid":{"revision_id":0,"type":"depid","value":"2000088"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02000088","sets":["1713853213384:1713853295607"]},"author_link":["415"],"control_number":"2000088","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Ectopic Fat and Distant Organ Insulin Resistance","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"e92170","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"PLOS ONE","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: The aim of this study was to examine the association between ectopic fat and organ-specific insulin resistance (IR) in insulin-target organs in patients with nonalcoholic fatty liver disease (NAFLD).\nMethods: Organ-specific IR in the liver (hepatic glucose production (HGP)×fasting plasma insulin (FPI) and suppression of HGP by insulin [%HGP]), skeletal muscle (insulin-stimulated glucose disposal [Rd]), and adipose tissue (suppression of FFA by insulin [%FFA]) was measured in 69 patients with NAFLD using a euglycemic hyperinsulinemic clamp with tracer infusion ([6,6-2H2]glucose). Liver fat, intramyocellular lipid (IMCL), and body composition were measured by liver biopsy, proton magnetic resonance spectroscopy, and bioelectrical impedance analysis, respectively.\nResults: HGP×FPI was significantly correlated with Rd (r = −0.57, P<0.001), %HGP with %FFA (r = 0.38, P<0.01), and Rd with %FFA (r = 0.27, P<0.05). Liver steatosis score was negatively associated with Rd (r = −0.47, P<0.001) as well as with HGP×FPI (r = 0.43, P<0.001). Similarly, intrahepatic lipid was negatively associated with Rd (r = −0.32, P<0.05). IMCL was not associated with Rd (r = −0.16, P = 0.26). Fat mass and its percentage were associated with HGP×FPI (r = 0.50, P<0.001; r = 0.48, P<0.001, respectively) and Rd (r = −0.59, P<0.001; r = −0.52, P<0.001, respectively), but not with %FFA (r = −0.21, P = 0.10; r = −0.001, P = 0.99, respectively).\nConclusion: Unexpectedly, fat accumulation in the skeletal muscle and adipose tissue was not associated with organ-specific IR. Instead, liver fat was associated not only with hepatic IR but also with skeletal muscle IR, suggesting a central role of fatty liver in systemic IR and that a network exists between liver and skeletal muscle.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"item_10001_rights_15","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"item_1722929371688","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1371/journal.pone.0092170"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0092170","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"item_1723180141928","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"278787"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Ken-ichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takamura, Toshinari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takeshita, Yumie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ryu, Yasuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Misu, Hirofumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ota, Tsuguhito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tokuyama, Kumpei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagasaka, Shoichiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松久, 宗英","creatorNameLang":"ja"},{"creatorName":"マツヒサ, ムネヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuhisa, Munehide","creatorNameLang":"en"}],"familyNames":[{"familyName":"松久","familyNameLang":"ja"},{"familyName":"マツヒサ","familyNameLang":"ja-Kana"},{"familyName":"Matsuhisa","familyNameLang":"en"}],"givenNames":[{"givenName":"宗英","givenNameLang":"ja"},{"givenName":"ムネヒデ","givenNameLang":"ja-Kana"},{"givenName":"Munehide","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"415","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"205776/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/205776/profile-ja.html"},{"nameIdentifier":"60362737","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60362737"}]},{"creatorNames":[{"creatorName":"Matsui, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kaneko, Shuichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2030-01-01"}],"displaytype":"detail","filename":"pone_9_3_e92170.pdf","filesize":[{"value":"312 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2000088/files/pone_9_3_e92170.pdf"},"version_id":"0d620b44-05c9-4ce0-b9b1-23d870c8fc4d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ectopic Fat Accumulation and Distant Organ-Specific Insulin Resistance in Japanese People with Nonalcoholic Fatty Liver Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ectopic Fat Accumulation and Distant Organ-Specific Insulin Resistance in Japanese People with Nonalcoholic Fatty Liver Disease","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"50","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-09-20"},"publish_date":"2024-09-20","publish_status":"0","recid":"2000088","relation_version_is_last":true,"title":["Ectopic Fat Accumulation and Distant Organ-Specific Insulin Resistance in Japanese People with Nonalcoholic Fatty Liver Disease"],"weko_creator_id":"50","weko_shared_id":-1},"updated":"2025-01-29T07:18:42.932083+00:00"}