{"created":"2024-09-24T02:00:01.431315+00:00","id":2000191,"links":{},"metadata":{"_buckets":{"deposit":"a1e6673c-3edf-46b5-934a-47943593e4d9"},"_deposit":{"created_by":50,"id":"2000191","owner":"50","owners":[50],"pid":{"revision_id":0,"type":"depid","value":"2000191"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02000191","sets":["1713853213384:1713853295607"]},"author_link":["325","337"],"control_number":"2000191","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"10- and 12-HODE as Biomarkers for Pre-Diabetes","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"e63542","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"PLOS ONE","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Current diagnostic tests such as glycemic indicators have limitations for early detection of impaired glucose tolerance (IGT), which leads to diabetes. Oxidative stress induced by various oxidants in a random and destructive manner is considered to play an important role in the pathophysiology of a number of human disorders and diseases such as impaired glucose tolerance. We have developed an improved method for the measurement of in vivo lipid peroxidation, where the presence of 8-iso-prostaglandin F2α (8-iso-PGF2α), hydroxyoctadecadienoic acids (HODEs), hydroxyeicosatetraenoic acids (HETEs), and 7-hydroxycholesterol (7-OHCh), as well as their parent molecules, linoleic acid (LA) and cholesterol (Ch), was determined by performing LC-MS/MS (for 8-iso-PGF2α, HODE, and HETE) and GC-MS (for 7-OHCh, LA, and Ch) after reduction with triphenyl phosphine and saponification by potassium hydroxide. We then applied this method to volunteers (n = 57), including normal type (n = 43), “high-normal” (fasting plasma glucose, 100–109 mg/dL, n = 7), pre-diabetic type (IGT, n = 5), and diabetic type (n = 2) subjects who are diagnosed by performing oral glucose tolerance tests (OGTTs). Several biomarkers in plasma, such as insulin, leptin, adiponectin, interleukin-6, tumor necrosis factor-α, high sensitivity-C-reactive protein, HbA1c, and glucose levels were measured during OGTT. We found that the fasting levels of (10- and 12-(Z,E)- HODE)/LA increased significantly with increasing levels of HbA1c and glucose during OGTT and with insulin secretion and resistance index. In conclusion, 10- and 12-(Z,E)-HODE may be prominent biomarkers for the early detection of IGT and “high-normal” type without OGTT.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"item_10001_rights_15","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Yoshiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"阿部, 佳織","creatorNameLang":"ja"},{"creatorName":"アベ, カオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Abe, Kaori","creatorNameLang":"en"}],"familyNames":[{"familyName":"阿部","familyNameLang":"ja"},{"familyName":"アベ","familyNameLang":"ja-Kana"},{"familyName":"Abe","familyNameLang":"en"}],"givenNames":[{"givenName":"佳織","givenNameLang":"ja"},{"givenName":"カオリ","givenNameLang":"ja-Kana"},{"givenName":"Kaori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"325","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60511326","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60511326"}]},{"creatorNames":[{"creatorName":"Kataoka, Masatoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshino, Kohzoh","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hagihara, Yoshihisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Aki, 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Diabetes","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"50","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-09"},"publish_date":"2024-10-09","publish_status":"0","recid":"2000191","relation_version_is_last":true,"title":["Singlet Oxygen Induced Products of Linoleates, 10- and 12-(Z,E)-Hydroxyoctadecadienoic Acids (HODE), Can Be Potential Biomarkers for Early Detection of Type 2 Diabetes"],"weko_creator_id":"50","weko_shared_id":-1},"updated":"2025-01-28T01:10:02.936805+00:00"}