{"created":"2024-09-26T06:53:35.071458+00:00","id":2000233,"links":{},"metadata":{"_buckets":{"deposit":"26d0a033-a3d8-4536-8e72-e4fcaeb79ae9"},"_deposit":{"created_by":50,"id":"2000233","owner":"50","owners":[50],"pid":{"revision_id":0,"type":"depid","value":"2000233"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02000233","sets":["1713853213384:1713853295607"]},"author_link":["424","1519"],"control_number":"2000233","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Tgε26 Integration Site","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"e14391","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"PLOS ONE","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A strain of human CD3ε transgenic mice, tgε26, exhibits severe immunodeficiency associated with early arrest of T cell development. Complete loss of T cells is observed in homozygous tgε26 mice, but not in heterozygotes, suggesting that genomic disruption due to transgenic integration may contribute to the arrest of T cell development. Here we report the identification of the transgenic integration site in tgε26 mice. We found that multiple copies of the human CD3ε transgene are inserted between the Sstr5 and Metrn loci on chromosome 17, and that this is accompanied by duplication of the neighboring genomic region spanning 323 kb. However, none of the genes in this region were abrogated. These results suggest that the severe immunodeficiency seen in tgε26 mice is not due to gene disruption resulting from transgenic integration.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"item_10001_rights_15","attribute_value_mlt":[{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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いずみ","creatorNameLang":"ja"},{"creatorName":"オオヒガシ, イズミ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohigashi, Izumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"大東","familyNameLang":"ja"},{"familyName":"オオヒガシ","familyNameLang":"ja-Kana"},{"familyName":"Ohigashi","familyNameLang":"en"}],"givenNames":[{"givenName":"いずみ","givenNameLang":"ja"},{"givenName":"イズミ","givenNameLang":"ja-Kana"},{"givenName":"Izumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"424","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"207340/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/207340/profile-ja.html"},{"nameIdentifier":"00596588","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00596588"}]},{"creatorNames":[{"creatorName":"Yamasaki, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirashima, Tsukasa","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"高浜, 洋介","creatorNameLang":"ja"},{"creatorName":"タカハマ, ヨウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahama, Yousuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"高浜","familyNameLang":"ja"},{"familyName":"タカハマ","familyNameLang":"ja-Kana"},{"familyName":"Takahama","familyNameLang":"en"}],"givenNames":[{"givenName":"洋介","givenNameLang":"ja"},{"givenName":"ヨウスケ","givenNameLang":"ja-Kana"},{"givenName":"Yousuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1519","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60028/profile-ja.html","nameIdentifierScheme":"徳島大学 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article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Identification of the Transgenic Integration Site in Immunodeficient tgε26 Human CD3ε Transgenic Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of the Transgenic Integration Site in Immunodeficient tgε26 Human CD3ε Transgenic Mice","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"50","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-11"},"publish_date":"2024-10-11","publish_status":"0","recid":"2000233","relation_version_is_last":true,"title":["Identification of the Transgenic Integration Site in Immunodeficient tgε26 Human CD3ε Transgenic Mice"],"weko_creator_id":"50","weko_shared_id":-1},"updated":"2025-02-10T06:50:28.046335+00:00"}