{"created":"2024-09-30T05:50:12.735259+00:00","id":2000259,"links":{},"metadata":{"_buckets":{"deposit":"2af81e9d-c30a-434a-b719-11c30e943f13"},"_deposit":{"created_by":52,"id":"2000259","owner":"52","owners":[52],"pid":{"revision_id":0,"type":"depid","value":"2000259"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02000259","sets":["1713853213384:1713853295607"]},"author_link":["301"],"control_number":"2000259","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-11-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"e57300","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"EMBO Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lysosomes are degradative organelles and signaling hubs that maintain cell and tissue homeostasis, and lysosomal dysfunction is implicated in aging and reduced longevity. Lysosomes are frequently damaged, but their repair mechanisms remain unclear. Here, we demonstrate that damaged lysosomal membranes are repaired by microautophagy (a process termed “microlysophagy”) and identify key regulators of the first and last steps. We reveal the AGC kinase STK38 as a novel microlysophagy regulator. Through phosphorylation of the scaffold protein DOK1, STK38 is specifically required for the lysosomal recruitment of the AAA+ ATPase VPS4, which terminates microlysophagy by promoting the disassembly of ESCRT components. By contrast, microlysophagy initiation involves non‐canonical lipidation of ATG8s, especially the GABARAP subfamily, which is required for ESCRT assembly through interaction with ALIX. Depletion of STK38 and GABARAPs accelerates DNA damage‐induced cellular senescence in human cells and curtails lifespan in C. elegans, respectively. Thus, microlysophagy is regulated by STK38 and GABARAPs and could be essential for maintaining lysosomal integrity and preventing aging.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"EMBO Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14693178","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Nao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tabata, Keisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Minami, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishino, Kohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nezu, Akiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hamasaki, Maho","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小迫, 英尊","creatorNameLang":"ja"},{"creatorName":"コサコ, ヒデタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kosako, Hidetaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"小迫","familyNameLang":"ja"},{"familyName":"コサコ","familyNameLang":"ja-Kana"},{"familyName":"Kosako","familyNameLang":"en"}],"givenNames":[{"givenName":"英尊","givenNameLang":"ja"},{"givenName":"ヒデタカ","givenNameLang":"ja-Kana"},{"givenName":"Hidetaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"301","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"172252/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/172252/profile-ja.html"},{"nameIdentifier":"10291171","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10291171"}]},{"creatorNames":[{"creatorName":"Yoshimori, Tamotsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Shuhei","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-01-01"}],"displaytype":"detail","filename":"embr_24_12_e57300.pdf","filesize":[{"value":"18 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2000259/files/embr_24_12_e57300.pdf"},"version_id":"9eee6326-0568-4e10-b149-dfece5f208ad"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ESCRT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lysosome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microautophagy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"non-canonical ATG8 lipidation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"52","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-06"},"publish_date":"2024-11-06","publish_status":"0","recid":"2000259","relation_version_is_last":true,"title":["Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging"],"weko_creator_id":"52","weko_shared_id":-1},"updated":"2025-01-29T06:55:15.072541+00:00"}