{"created":"2024-10-02T04:03:33.149689+00:00","id":2000297,"links":{},"metadata":{"_buckets":{"deposit":"a9d928da-c2d2-4cf5-bc74-48630656f1ce"},"_deposit":{"created_by":50,"id":"2000297","owner":"50","owners":[50],"pid":{"revision_id":0,"type":"depid","value":"2000297"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02000297","sets":["1713853213384:1713853295607"]},"author_link":["501","564","183","309"],"control_number":"2000297","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"30","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Cardiovascular Diabetology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Azilsartan, an angiotensin II type 1 (AT1) receptor blocker (ARB), has a higher affinity for and slower dissociation from AT1 receptors and shows stronger inverse agonism compared to other ARBs. Possible benefits of azilsartan in diabetic vascular dysfunction have not been established.\nMethods: We measured vascular reactivity of aortic rings in male KKAy diabetic mice treated with vehicle, 0.005% azilsartan, or 0.005% candesartan cilexetil for 3 weeks. Expression of markers of inflammation and oxidative stress was measured using semiquantitative RT-PCR in the vascular wall, perivascular fat, and skeletal muscle. Phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser1177 and Thr495 was measured using Western blotting, and the ratio of phosphorylation at Ser1177 to phosphorylation at Thr495 was used as a putative indicator of vascular eNOS activity.\nResults: (1) Vascular endothelium–dependent relaxation with acetylcholine in KKAy mice was improved by azilsartan treatment compared to candesartan cilexetil; (2) the ratio of Ser1177/Thr495 phosphorylation of eNOS was impaired in KKAy and was effectively restored by azilsartan; (3) anomalies in the expression levels of monocyte chemotactic protein 1 (MCP1), F4/80, NAD(P)H oxidase (Nox) 2, and Nox4 of the aortic wall and in the expression of TNFα in the perivascular fat were strongly attenuated by azilsartan compared to candesartan cilexetil.\nConclusions: These results provide evidence that azilsartan prevents endothelial dysfunction in diabetic mice, more potently than does candesartan cilexetil. Azilsartan’s higher affinity for and slower dissociation from AT1 receptors may underlie its efficacy in diabetic vascular dysfunction via a dual effect on uncoupled eNOS and on Nox.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"},{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14752840","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/1475-2840-13-30"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/1475-2840-13-30","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"274562"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Sachiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"島袋, 充生","creatorNameLang":"ja"},{"creatorName":"シマブクロ, ミチオ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimabukuro, Michio","creatorNameLang":"en"}],"familyNames":[{"familyName":"島袋","familyNameLang":"ja"},{"familyName":"シマブクロ","familyNameLang":"ja-Kana"},{"familyName":"Shimabukuro","familyNameLang":"en"}],"givenNames":[{"givenName":"充生","givenNameLang":"ja"},{"givenName":"ミチオ","givenNameLang":"ja-Kana"},{"givenName":"Michio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"501","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60271144","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60271144"}]},{"creatorNames":[{"creatorName":"福田, 大受","creatorNameLang":"ja"},{"creatorName":"フクダ, ダイジュ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuda, Daiju","creatorNameLang":"en"}],"familyNames":[{"familyName":"福田","familyNameLang":"ja"},{"familyName":"フクダ","familyNameLang":"ja-Kana"},{"familyName":"Fukuda","familyNameLang":"en"}],"givenNames":[{"givenName":"大受","givenNameLang":"ja"},{"givenName":"ダイジュ","givenNameLang":"ja-Kana"},{"givenName":"Daiju","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"564","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40637568","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40637568"}]},{"creatorNames":[{"creatorName":"添木, 武","creatorNameLang":"ja"},{"creatorName":"ソエキ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Soeki, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"添木","familyNameLang":"ja"},{"familyName":"ソエキ","familyNameLang":"ja-Kana"},{"familyName":"Soeki","familyNameLang":"en"}],"givenNames":[{"givenName":"武","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"183","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"121162/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/121162/profile-ja.html"},{"nameIdentifier":"60393211","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60393211"}]},{"creatorNames":[{"creatorName":"Yamakawa, Ken","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Masuzaki, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"},{"creatorName":"サタ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Sata, Masataka","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐田","familyNameLang":"ja"},{"familyName":"サタ","familyNameLang":"ja-Kana"},{"familyName":"Sata","familyNameLang":"en"}],"givenNames":[{"givenName":"政隆","givenNameLang":"ja"},{"givenName":"マサタカ","givenNameLang":"ja-Kana"},{"givenName":"Masataka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"173932/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/173932/profile-ja.html"},{"nameIdentifier":"80345214","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80345214"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-02-20"}],"displaytype":"detail","filename":"cardiab_13_30.pdf","filesize":[{"value":"639 KB"}],"format":"application/pdf","license_note":"https://creativecommons.org/licenses/by/2.0","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2000297/files/cardiab_13_30.pdf"},"version_id":"0977feb1-1e02-455d-8c30-93f003beaa16"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Telmisartan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Olmesartan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Candesartan Cilexetil","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulin Tolerance Test","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Reactive Oxidant Species","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic mice","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"50","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-20"},"publish_date":"2025-02-20","publish_status":"0","recid":"2000297","relation_version_is_last":true,"title":["Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic mice"],"weko_creator_id":"50","weko_shared_id":-1},"updated":"2025-02-20T02:10:44.690194+00:00"}