| Item type |
文献 / Documents(1) |
| 公開日 |
2025-06-23 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1159/000356675 |
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関連名称 |
10.1159/000356675 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Genipin Inhibits IL-1β-Induced CCL20 and IL-6 Production from Human Periodontal Ligament Cells |
| タイトル別表記 |
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その他のタイトル |
Genipin Inhibits IL-6 and CCL20 Productions |
| 著者 |
Shindo, Satoru
細川, 義隆
細川, 育子
尾崎, 和美
松尾, 敬志
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| 抄録 |
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内容記述 |
Background/Aims: Genipin, the aglycon of geniposide found in gardenia fruit has long been considered for treatment of various diseases in traditional oriental medicine. Genipin has been used as a blue colorant in food industry. Genipin has recently been reported to have some pharmacological functions, such as antimicrobial, antitumor, and anti-inflammatory effects. The aim of this study was to examine whether genipin could modify CCL20 and IL-6, which are related to bone resorption in periodontal disease, expression in human periodontal ligament cells (HPDLCs). Methods: CCL20 and IL-6 productions from HPDLCs were determined by ELISA. Western blot analysis was used for the detection of signal transduction molecules expressions in HPDLCs. Results: Genipin prevented IL-1ß-mediated CCL20 and IL-6 production in HPDLCs. Moreover, genipin could suppress nuclear factor kappa B (NF-κB) p65, extracellular signalregulated kinase (ERK) and MAPK/ERK kinase (MEK) phosphorylations in IL-1ß-stimulated HPDLCs. NF-κB inhibitor and ERK inhibitor significantly inhibited IL-6 and CCL20 productions from IL-1ß-stimulated HPDLCs. Conclusions: These data provide a novel mechanism through which genipin could be used to provide direct benefits in periodontal disease to inhibit IL-6 and CCL20 productions in periodontal lesions. |
| キーワード |
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主題 |
Genipin |
| キーワード |
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主題 |
IL-6 |
| キーワード |
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主題 |
CCL20 |
| キーワード |
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|
主題 |
NF-κB |
| キーワード |
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|
主題 |
MAPKs |
| キーワード |
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|
主題 |
Periodontal ligament cells |
| 書誌情報 |
en : Cellular Physiology and Biochemistry
巻 33,
号 2,
p. 357-364,
発行日 2014-02-06
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
14219778 |
| 収録物ID |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
10158987 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12780988 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10801409 |
| 出版者 |
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出版者 |
S. Karger AG, Basel |
| 権利情報 |
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権利情報 |
This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only. |
| EID |
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識別子 |
279331 |
| 言語 |
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|
言語 |
eng |
cell_physiol_biochem_33_2_357.pdf (967 KB)
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