{"created":"2024-10-04T01:29:42.336927+00:00","id":2000325,"links":{},"metadata":{"_buckets":{"deposit":"91e32a76-d7cb-4188-8c0f-2a972b6fd570"},"_deposit":{"created_by":52,"id":"2000325","owner":"52","owners":[52],"pid":{"revision_id":0,"type":"depid","value":"2000325"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02000325","sets":["1713853213384:1713853295607"]},"author_link":["301"],"control_number":"2000325","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-02-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"109107","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"iScience","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Most mammalian cells prevent viral infection and proliferation by expressing various restriction factors and sensors that activate the immune system. Several host restriction factors that inhibit human immunodeficiency virus type 1 (HIV-1) have been identified, but most of them are antagonized by viral proteins. Here, we describe CCHC-type zinc-finger-containing protein 3 (ZCCHC3) as a novel HIV-1 restriction factor that suppresses the production of HIV-1 and other retroviruses, but does not appear to be directly antagonized by viral proteins. It acts by binding to Gag nucleocapsid (GagNC) via zinc-finger motifs, which inhibits viral genome recruitment and results in genome-deficient virion production. ZCCHC3 also binds to the long terminal repeat on the viral genome via the middle-folded domain, sequestering the viral genome to P-bodies, which leads to decreased viral replication and production. This distinct, dual-acting antiviral mechanism makes upregulation of ZCCHC3 a novel potential therapeutic strategy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"25890042","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.isci.2024.109107"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.isci.2024.109107","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"409525"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yi, Binbin","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Yuri L.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Cornish, Daphne","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小迫, 英尊","creatorNameLang":"ja"},{"creatorName":"コサコ, ヒデタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kosako, Hidetaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"小迫","familyNameLang":"ja"},{"familyName":"コサコ","familyNameLang":"ja-Kana"},{"familyName":"Kosako","familyNameLang":"en"}],"givenNames":[{"givenName":"英尊","givenNameLang":"ja"},{"givenName":"ヒデタカ","givenNameLang":"ja-Kana"},{"givenName":"Hidetaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"301","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"172252/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/172252/profile-ja.html"},{"nameIdentifier":"10291171","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10291171"}]},{"creatorNames":[{"creatorName":"Butlertanaka, Erika P.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sengupta, Prabuddha","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Lippincott-Schwartz, Jennifer","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hultquist, Judd F.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saito, Akatsuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshimura, Shige H.","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-03-21"}],"displaytype":"detail","filename":"isci_27_3_109107.pdf","filesize":[{"value":"6.5 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2000325/files/isci_27_3_109107.pdf"},"version_id":"149c11ec-b43a-4f7f-baf8-f924f78c9b6a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"52","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-21"},"publish_date":"2025-03-21","publish_status":"0","recid":"2000325","relation_version_is_last":true,"title":["Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism"],"weko_creator_id":"52","weko_shared_id":-1},"updated":"2025-03-21T05:57:33.869601+00:00"}