| Item type |
文献 / Documents(1) |
| 公開日 |
2025-06-24 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
|
関連識別子 |
https://doi.org/10.7150/thno.9199 |
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|
関連名称 |
10.7150/thno.9199 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release |
| 著者 |
林, 幸壱朗
中村, 教泰
三木, 浩和
Ozaki, Shuji
安倍, 正博
松本, 俊夫
Sakamoto, Wataru
Yogo, Toshinobu
石村, 和敬
|
| 抄録 |
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内容記述 |
We report the synthesis of smart nanoparticles (NPs) that generate heat in response to an alternating current magnetic field (ACMF) and that sequentially release an anticancer drug (doxorubicin, DOX). We further study the in vivo therapeutic efficacy of the combination of magnetic hyperthermia (MHT) and chemotherapy using the smart NPs for the treatment of multiple myeloma. The smart NPs are composed of a polymer with a glass-transition temperature (Tg) of 44°C, which contains clustered Fe3O4 NPs and DOX. The clustered Fe3O4 NPs produce heat when the ACMF is applied and rise above 44°C, which softens the polymer phase and leads to the release of DOX. The combination of MHT and chemotherapy using the smart NPs destroys cancer cells in the entire tumor and achieves a complete cure in one treatment without the recurrence of malignancy. Furthermore, the smart NPs have no significant toxicity. |
| キーワード |
|
|
主題 |
smart nanoparticles |
| キーワード |
|
|
主題 |
alternating current magnetic field |
| キーワード |
|
|
主題 |
cancer cells |
| 書誌情報 |
en : Theranostics
巻 4,
号 8,
p. 834-844,
発行日 2014-06-07
|
| 収録物ID |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
18387640 |
| 出版者 |
|
|
出版者 |
Ivyspring International Publisher |
| 権利情報 |
|
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
| EID |
|
|
識別子 |
286935 |
| 言語 |
|
|
言語 |
eng |
Theranostics_4_8_834.pdf (2.6 MB)
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