{"created":"2024-10-04T02:48:02.994332+00:00","id":2000327,"links":{},"metadata":{"_buckets":{"deposit":"b72a2d04-1719-40bf-8ce6-2b1eb9d468cb"},"_deposit":{"created_by":52,"id":"2000327","owner":"52","owners":[52],"pid":{"revision_id":0,"type":"depid","value":"2000327"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02000327","sets":["1713853213384:1713853295607"]},"author_link":["917"],"control_number":"2000327","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-01-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"105766","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"iScience","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Clustered protocadherin is a family of cell-surface recognition molecules implicated in neuronal connectivity that has a diverse isoform repertoire and homophilic binding specificity. Mice have 58 isoforms, encoded by Pcdhα, β, and γ gene clusters, and mutant mice lacking all isoforms died after birth, displaying massive neuronal apoptosis and synapse loss. The current hypothesis is that the three specific γC-type isoforms, especially γC4, are essential for the phenotype, raising the question about the necessity of isoform diversity. We generated TC mutant mice that expressed the three γC-type isoforms but lacked all the other 55 isoforms. The TC mutants died immediately after birth, showing massive neuronal death, and γC3 or γC4 expression did not prevent apoptosis. Restoring the α- and β-clusters with the three γC alleles rescued the phenotype, suggesting that along with the three γC-type isoforms, other isoforms are also required for the survival of neurons and individual mice.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"25890042","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.isci.2022.105766"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.isci.2022.105766","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"406750"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kobayashi, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takemoto, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sanbo, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirabayashi, Masumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirabayashi, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"平山, 晃斉","creatorNameLang":"ja"},{"creatorName":"ヒラヤマ, テルヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirayama, Teruyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"平山","familyNameLang":"ja"},{"familyName":"ヒラヤマ","familyNameLang":"ja-Kana"},{"familyName":"Hirayama","familyNameLang":"en"}],"givenNames":[{"givenName":"晃斉","givenNameLang":"ja"},{"givenName":"テルヨシ","givenNameLang":"ja-Kana"},{"givenName":"Teruyoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"917","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"337324/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/337324/profile-ja.html"}]},{"creatorNames":[{"creatorName":"Kiyonari, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Abe, Takaya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yagi, Takeshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-03-03"}],"displaytype":"detail","filename":"isci_26_1_105766.pdf","filesize":[{"value":"6.7 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2000327/files/isci_26_1_105766.pdf"},"version_id":"9f4435ca-71a5-420e-9836-3656d92bbd48"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"52","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-03"},"publish_date":"2025-03-03","publish_status":"0","recid":"2000327","relation_version_is_last":true,"title":["Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality"],"weko_creator_id":"52","weko_shared_id":-1},"updated":"2025-03-03T02:39:42.289046+00:00"}