| Item type |
文献 / Documents(1) |
| 公開日 |
2025-06-24 |
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.7150/thno.5860 |
|
|
関連名称 |
10.7150/thno.5860 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Superparamagnetic Nanoparticle Clusters for Cancer Theranostics Combining Magnetic Resonance Imaging and Hyperthermia Treatment |
| 著者 |
林, 幸壱朗
中村, 教泰
Sakamoto, Wataru
Yogo, Toshinobu
三木, 浩和
Ozaki, Shuji
安倍, 正博
松本, 俊夫
石村, 和敬
|
| 抄録 |
|
|
内容記述 |
Superparamagnetic nanoparticles (SPIONs) could enable cancer theranostics if magnetic resonance imaging (MRI) and magnetic hyperthermia treatment (MHT) were combined. However, the particle size of SPIONs is smaller than the pores of fenestrated capillaries in normal tissues because superparamagnetism is expressed only at a particle size <10 nm. Therefore, SPIONs leak from the capillaries of normal tissues, resulting in low accumulation in tumors. Furthermore, MHT studies have been conducted in an impractical way: direct injection of magnetic materials into tumor and application of hazardous alternating current (AC) magnetic fields. To accomplish effective enhancement of MRI contrast agents in tumors and inhibition of tumor growth by MHT with intravenous injection and a safe AC magnetic field, we clustered SPIONs not only to prevent their leakage from fenestrated capillaries in normal tissues, but also for increasing their relaxivity and the specific absorption rate. We modified the clusters with folic acid (FA) and polyethylene glycol (PEG) to promote their accumulation in tumors. SPION clustering and cluster modification with FA and PEG were achieved simultaneously via the thiol-ene click reaction. Twenty-four hours after intravenous injection of FA- and PEG-modified SPION nanoclusters (FA-PEG-SPION NCs), they accumulated locally in cancer (not necrotic) tissues within the tumor and enhanced the MRI contrast. Furthermore, 24 h after intravenous injection of the NCs, the mice were placed in an AC magnetic field with H = 8 kA/m and f = 230 kHz (Hf = 1.8×109 A/m∙s) for 20 min. The tumors of the mice underwent local heating by application of an AC magnetic field. The temperature of the tumor was higher than the surrounding tissues by ≈6°C at 20 min after treatment. Thirty-five days after treatment, the tumor volume of treated mice was one-tenth that of the control mice. Furthermore, the treated mice were alive after 12 weeks; control mice died up to 8 weeks after treatment. |
| キーワード |
|
|
主題 |
theranostics |
| キーワード |
|
|
主題 |
nanomedicine |
| キーワード |
|
|
主題 |
iron oxide |
| キーワード |
|
|
主題 |
MRI |
| キーワード |
|
|
主題 |
hyperthermia |
| キーワード |
|
|
主題 |
tumor |
| 書誌情報 |
en : Theranostics
巻 3,
号 6,
p. 366-376,
発行日 2013-04-23
|
| 収録物ID |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
18387640 |
| 出版者 |
|
|
出版者 |
Ivyspring International Publisher |
| 権利情報 |
|
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
| EID |
|
|
識別子 |
264550 |
| 言語 |
|
|
言語 |
eng |
Theranostics_3_6_366.pdf (1.8 MB)
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