| Item type |
文献 / Documents(1) |
| 公開日 |
2025-06-24 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1159/000350114 |
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|
関連名称 |
10.1159/000350114 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
(-)-Epigallocatechin-3-Gallate Inhibits CC Chemokine Ligand 11 Production in Human Gingival Fibroblasts |
| タイトル別表記 |
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その他のタイトル |
EGCG Inhibits CCL11 Production in Puman Gingival Fibroblasts |
| 著者 |
細川, 義隆
細川, 育子
Shindo, Satoru
尾崎, 和美
松尾, 敬志
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| 抄録 |
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内容記述 |
Background: CC chemokine ligand 11 (CCL11) is related to Th2 cells migration via CC chemokine receptor 3 (CCR3). Th2 cells are involved in the etiology of periodontal disease. However, how the infiltration of Th2 cells is controlled in periodontally diseased tissues is unknown. (-)-Epigallocatechin gallate (EGCG), the major catechin in green tea, has multiple beneficial effects, but the effects of EGCG on CCL11 production are uncertain. In this study, we investigated whether cytokines could induce CCL11 production in human gingival fibroblasts (HGFs). Moreover, we examined the effects of EGCG on CCL11 production in HGFs. Methods and Results: ELISA analysis disclosed that interleukin (IL)-4 synergistically enhanced CCL11 production in IL-1β or tumor necrosis factor (TNF)-α-stimulated HGFs. EGCG prevented IL-1β/ IL-4 or TNF-α/IL-4-mediated CCL11 production in a concentration dependent manner. CCL11 production in HGFs was positively regulated by p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), and c-Jun N terminal kinase (JNK). Western blot analysis revealed that EGCG treatment prevented IL-1β/IL-4 or TNF-α/IL-4-induced ERK and JNK activation in HGFs. Conclusions: These data provide that CCL11 production in HGFs could be associated with Th2 cells infiltration in periodontal lesions. Moreover, EGCG is useful for periodontitis treatment to inhibit CCL11 production. |
| キーワード |
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|
主題 |
Green tea catechin |
| キーワード |
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|
主題 |
Human gingival fibroblast |
| キーワード |
|
|
主題 |
CCL11 |
| キーワード |
|
|
主題 |
MAPK |
| 書誌情報 |
en : Cellular Physiology and Biochemistry
巻 31,
号 6,
p. 960-967,
発行日 2013-06-26
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
14219778 |
| 収録物ID |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
10158987 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12780988 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10801409 |
| 出版者 |
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|
出版者 |
S. Karger AG, Basel |
| 権利情報 |
|
|
権利情報 |
This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License (www.karger.com/OA-license), applicable to the online version of the article only. Distribution for non-commercial purposes only. |
| EID |
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|
識別子 |
264738 |
| 言語 |
|
|
言語 |
eng |
cell_physiol_biochem_31_6_960.pdf (1.1 MB)
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