{"created":"2024-10-07T05:07:21.022428+00:00","id":2000339,"links":{},"metadata":{"_buckets":{"deposit":"08ce280a-e965-4205-841f-ff36ee268327"},"_deposit":{"created_by":51,"id":"2000339","owner":"51","owners":[51],"pid":{"revision_id":0,"type":"depid","value":"2000339"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02000339","sets":["1713853213384:1713853295607"]},"author_link":["527"],"control_number":"2000339","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3652","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Human mesenchymal stem cells (hMSCs) remodel or regenerate various tissues through several mechanisms. Here, we identified the hMSC-secreted protein SCRG1 and its receptor BST1 as a positive regulator of self-renewal, migration and osteogenic differentiation. SCRG1 and BST1 gene expression decreased during osteogenic differentiation of hMSCs. Intriguingly, SCRG1 maintained stem cell marker expression (Oct-4 and CD271/LNGFR) and the potentials of self-renewal, migration and osteogenic differentiation, even at high passage numbers. Thus, the novel SCRG1/BST1 axis determines the fate of hMSCs by regulating their kinetic and differentiation potentials. Our findings provide a new perspective on methods for ex vivo expansion of hMSCs that maintain native stem cell potentials for bone-forming cell therapy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution NonCommercial-NoDerivs 3.0 Unported license. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/srep03652"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/srep03652","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"279622"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Aomatsu, Emiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takahashi, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sawada, Shunsuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okubo, Naoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"長谷川, 智一","creatorNameLang":"ja"},{"creatorName":"ハセガワ, トモカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Hasegawa, Tomokazu","creatorNameLang":"en"}],"familyNames":[{"familyName":"長谷川","familyNameLang":"ja"},{"familyName":"ハセガワ","familyNameLang":"ja-Kana"},{"familyName":"Hasegawa","familyNameLang":"en"}],"givenNames":[{"givenName":"智一","givenNameLang":"ja"},{"givenName":"トモカズ","givenNameLang":"ja-Kana"},{"givenName":"Tomokazu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"527","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"229264/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/229264/profile-ja.html"},{"nameIdentifier":"50274668","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50274668"}]},{"creatorNames":[{"creatorName":"Taira, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miura, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishisaki, Akira","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Chosa, Naoyuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-03-04"}],"displaytype":"detail","filename":"srep_4_3652.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2000339/files/srep_4_3652.pdf"},"version_id":"02070e75-5ff6-4e08-a3fa-60dd56dea86c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Novel SCRG1/BST1 axis regulates self-renewal, migration and osteogenic differentiation potential in mesenchymal stem cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Novel SCRG1/BST1 axis regulates self-renewal, migration and osteogenic differentiation potential in mesenchymal stem cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"51","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-04"},"publish_date":"2025-03-04","publish_status":"0","recid":"2000339","relation_version_is_last":true,"title":["Novel SCRG1/BST1 axis regulates self-renewal, migration and osteogenic differentiation potential in mesenchymal stem cells"],"weko_creator_id":"51","weko_shared_id":-1},"updated":"2025-03-04T06:02:24.164924+00:00"}