{"created":"2024-10-09T10:18:59.258921+00:00","id":2000955,"links":{},"metadata":{"_buckets":{"deposit":"dd530fd3-3ce6-41bc-875a-c17037d36831"},"_deposit":{"created_by":7,"id":"2000955","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2000955"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02000955","sets":["1713829974766:1713854681789:1716364521058:1716421648311","1713853213384:1713853295607"]},"author_link":["1118"],"control_number":"2000955","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"150","bibliographicPageStart":"141","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The molecular basis of lymphoid organogenesis has recently been elucidated using gene-targeted mice. Mice deficient in lymphotoxin-α (LTα) lack lymph nodes and Peyer's patches. The action of LTα in lymphoid organogenesis is mediated mostly by the membrane form of LT by a mechanism independent of TNF receptor I (TNFR-I) or II (TNFR-II). Additionally, follicular dendritic cell (FDC) clusters or germinal centers fail to develop in the spleen of LTα-deficient mice. Mice deficient in either TNFR-I or LTβR also fail to develop splenic FDC clusters and germinal centers, indicating that signaling through both TNFR-I and LTβR is required for the development of these structures. The mechanisms underlying the defective lymphoid organogenesis in LTα-deficient mice, together with a natural mutant strain, alymphoplasia (aly) mice, which manifest a quite similar phenotype to LTα-deficient mice, were investigated by generating aggregation chimeras. These studies demonstrate that LTα and the aly gene product together control lymphoid organogenesis with a close mechanistic relationship in their biochemical pathways through governing distinct cellular compartments;the former acting as a circulating ligand and the latter as a LTβR-signaling molecule expressed by the stroma of the lymphoid organs.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"データ元 : http://medical.med.tokushima-u.ac.jp/jmi/"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"72145"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松本, 満","creatorNameLang":"ja"},{"creatorName":"マツモト, ミツル","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Mitsuru","creatorNameLang":"en"}],"familyNames":[{"familyName":"松本","familyNameLang":"ja"},{"familyName":"マツモト","familyNameLang":"ja-Kana"},{"familyName":"Matsumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"満","givenNameLang":"ja"},{"givenName":"ミツル","givenNameLang":"ja-Kana"},{"givenName":"Mitsuru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1118","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60604/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60604/profile-ja.html"},{"nameIdentifier":"60221595","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60221595"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2011-11-17"}],"displaytype":"detail","filename":"LID201111172003.pdf","filesize":[{"value":"164 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2000955/files/LID201111172003.pdf"},"version_id":"2380dc59-383f-4a83-bc89-b11e0123e7df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lymphotoxin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lymph node","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"spleen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"knockout mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Role of TNF Ligand and Receptor Family in the Lymphoid Organogenesis Defined by Gene Targeting","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of TNF Ligand and Receptor Family in the Lymphoid Organogenesis Defined by Gene Targeting","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716421648311"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-11-22"},"publish_date":"2011-11-22","publish_status":"0","recid":"2000955","relation_version_is_last":true,"title":["Role of TNF Ligand and Receptor Family in the Lymphoid Organogenesis Defined by Gene Targeting"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T04:18:24.028285+00:00"}