{"created":"2024-10-09T10:19:02.845332+00:00","id":2000956,"links":{},"metadata":{"_buckets":{"deposit":"addd643a-e93a-4b1e-8861-3ddc91f99be2"},"_deposit":{"created_by":7,"id":"2000956","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2000956"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02000956","sets":["1713829974766:1713854681789:1716364521058:1716421655957","1713853213384:1713853295607"]},"author_link":["168","1141"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Nonapeptide bradykinin is known to be a central nervous system neurotrans-mitter and to play a role in regulation of neuronal function. However, few details are known of the function of its peptide on stimulus-secretion coupling in neuronal cells. In this article, the role of bradykinin on catecholamine biosynthesis, secretion and Ca2+movement in adrenal chromaffin cells as a model for catecholamine-containing neurons are examined. Bradykinin receptors are classified as B1 and B2 receptor subtypes. These receptors are present on the adrenal chromaffin cell membrane. Bradykinin increases the influx of Ca2+ and the turnover of phosphoinositide through the stimulation of bradykinin B2 receptor. The secretion of catecholamine from the cells is initiated by the raise of [Ca2+]i. An increase in [Ca2+]i and production of diacylglycerol stimulate the activation of calcium-dependent protein kinases. These kinases stimulate the activation of tyrosine hydroxylase, a rate-limiting enzyme in the biosynthesis of catecholamine. Otherwise, bradykinin increases Ca2+ efflux from the cells through the stimulation of the bradykinin-B2 receptor. This action may be explained by an extracellular Na+-dependent mechanism, probably through acceleration of Na+/Ca2+ exchange. It is interesting that bradykinin, which stimulates the biosynthesis and secretion of catecholamine in adrenal chromaffin cells, plays a role in the termination of calcium-signal transduction through the stimu-lation of Ca2+ efflux from the cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"データ元 : http://medical.med.tokushima-u.ac.jp/jmi/"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"131141"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ホウチ, ヒトシ","creatorNameLang":"ja"},{"creatorName":"ホウチ, ヒトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Houchi, Hitoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"東, 満美","creatorNameLang":"ja"},{"creatorName":"アズマ, マミ","creatorNameLang":"ja-Kana"},{"creatorName":"Azuma, Mami","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉栖, 正典","creatorNameLang":"ja"},{"creatorName":"ヨシズミ, マサノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshizumi, Masanori","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"玉置, 俊晃","creatorNameLang":"ja"},{"creatorName":"タマキ, トシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tamaki, Toshiaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"玉置","familyNameLang":"ja"},{"familyName":"タマキ","familyNameLang":"ja-Kana"},{"familyName":"Tamaki","familyNameLang":"en"}],"givenNames":[{"givenName":"俊晃","givenNameLang":"ja"},{"givenName":"トシアキ","givenNameLang":"ja-Kana"},{"givenName":"Toshiaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"168","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10948/profile-ja.html","nameIdentifierScheme":"徳島大学 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Kazuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"水口","familyNameLang":"ja"},{"familyName":"ミナクチ","familyNameLang":"ja-Kana"},{"familyName":"Minakuchi","familyNameLang":"en"}],"givenNames":[{"givenName":"和生","givenNameLang":"ja"},{"givenName":"カズオ","givenNameLang":"ja-Kana"},{"givenName":"Kazuo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1141","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60640/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60640/profile-ja.html"},{"nameIdentifier":"30284326","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30284326"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2011-11-16"}],"displaytype":"detail","filename":"LID201111162001.pdf","filesize":[{"value":"426 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2000956/files/LID201111162001.pdf"},"version_id":"e21b5a5b-935f-4422-ae24-e8459a3ea7a1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bradykinin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Catecholamine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biosynthesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Secretion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcium","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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