{"created":"2024-10-09T10:26:48.787919+00:00","id":2001053,"links":{},"metadata":{"_buckets":{"deposit":"d8032644-83d8-4df9-8701-94fa51c9e899"},"_deposit":{"created_by":7,"id":"2001053","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2001053"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02001053","sets":["1713829974766:1713854682253:1716422254419:1716424781127","1713853213384:1713853295607"]},"author_link":["1549"],"control_number":"2001053","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Sleep and Biological Clock","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-05-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"13","bibliographicPageStart":"8","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"四国医学雑誌","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Circadian rhythm is an endogenous rhythm controlled by a master oscillator (biological clock) in the supra-chiasmatic nucleus (SCN), affecting on the almost all physiological functions including sleep/wake regulation. Recently the biological clock has been shown to function at the molecular level, and several circadian-related genes have been identified, such as the Clock, Per 1-3, Bmal 1 or Cry 1, 2.\nWe observed the sleep/wake rhythm in cry 1, 2 double knockout mice and clock mutant mice. Both strains have lost the circadian oscillation in the expression of circadian-related genes. Cry 1, 2 double knockout mice show the entrained sleep/wake rhythm to ordinary light-dark (LD) cycle, although they show completely flattened rhythm under the constant dark (DD) condition. On the other hand, clock mutant mice show the persistent circadian sleep/wake rhythm under even DD conditions. Although the expression of circadian-related genes do not oscillate, the clock mutant mice have potent circadian rhythm in body core temperature, behavior, sleep/wake and cortisol etc. The clock mutant mice have a longer (27 hrs) period of free-running rhythm under DD condition, and the phase of sleep/wake rhythm is delayed for about two hours comparing to the wild-type under LD condition.\nThe important role of the circadian-related genes in the sleep/wake regulation has been indicated. The functional impairment of the circadian-related genes may be involved in the sleep disorders, such as insomnia or hypersomnia.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"徳島医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00373699","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00102041","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"四国医学雑誌 : http://www.tokushima-u.ac.jp/med/research/shikoku_acta_medica.html"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"136559"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"勢井, 宏義","creatorNameLang":"ja"},{"creatorName":"セイ, ヒロヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sei, Hiroyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"勢井","familyNameLang":"ja"},{"familyName":"セイ","familyNameLang":"ja-Kana"},{"familyName":"Sei","familyNameLang":"en"}],"givenNames":[{"givenName":"宏義","givenNameLang":"ja"},{"givenName":"ヒロヨシ","givenNameLang":"ja-Kana"},{"givenName":"Hiroyoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1549","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60076/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60076/profile-ja.html"},{"nameIdentifier":"40206602","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40206602"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2012-08-29"}],"displaytype":"detail","filename":"LID201208292006.pdf","filesize":[{"value":"140 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2001053/files/LID201208292006.pdf"},"version_id":"92cd2d7a-bcc1-4e54-9402-79fbcf5ca988"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"circadian","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sleep","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"circadian-related genes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"睡眠と生体リズム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"睡眠と生体リズム","subitem_title_language":"ja"},{"subitem_title":"スイミン ト セイタイ リズム","subitem_title_language":"ja-Kana"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716424781127"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-08-29"},"publish_date":"2012-08-29","publish_status":"0","recid":"2001053","relation_version_is_last":true,"title":["睡眠と生体リズム"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-14T00:12:37.566015+00:00"}