{"created":"2024-10-09T10:31:14.017033+00:00","id":2001113,"links":{},"metadata":{"_buckets":{"deposit":"7bc157b4-5c5d-4b45-b644-fd975e0552e2"},"_deposit":{"created_by":7,"id":"2001113","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2001113"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02001113","sets":["1713829974766:1713854680413:1716363996082","1713853213384:1713853297799"]},"author_link":["116","113"],"control_number":"2001113","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Design, ex vivo Synthesis, and Biological Activities of Plant Constituents Containing an Isoprene Side-chain Based on Isoprenomics","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"56","bibliographicPageStart":"52","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"徳島大学大学院ソシオテクノサイエンス研究部研究報告","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Phytyl quinols, namely acyclic tocopherols, are key intermediates of tocopherol biosynthesis,\nbut their biological activities remain unclear. We therefore investigated the structure-activity\nrelationship of phytyl quinols to apply a chemical biosynthesis design for an antiatherosclerosis\ndrug based on isoprenomics. We have achieved the biosynthesis-oriented synthesis of α- and\nβ-phytyl quinol as an unnatural intermediate, other γ- and δ-phytyl quinol as a natural one. All four\nphytyl quinols showed almost the same moderate inhibitory activity against low-density lipoprotein\noxidation instead of their different degree of C-methylation with character different from\ntocopherols. In vivo toxicities of phytyl quinols against chick embryo chorioallantoic membrane\nvasculature were hardly observed. We proposed phytyl quinols were possible antioxidants in plants\nand animals, like vitamin E.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"徳島大学大学院ソシオテクノサイエンス研究部","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"21859094","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12214889","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"188358"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"宇都, 義浩","creatorNameLang":"ja"},{"creatorName":"ウト, ヨシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Uto, Yoshihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"宇都","familyNameLang":"ja"},{"familyName":"ウト","familyNameLang":"ja-Kana"},{"familyName":"Uto","familyNameLang":"en"}],"givenNames":[{"givenName":"義浩","givenNameLang":"ja"},{"givenName":"ヨシヒロ","givenNameLang":"ja-Kana"},{"givenName":"Yoshihiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"116","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10780/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/10780/profile-ja.html"},{"nameIdentifier":"20304553","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20304553"}]},{"creatorNames":[{"creatorName":"小山, 大輔","creatorNameLang":"ja"},{"creatorName":"コヤマ, ダイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Koyama, Daisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大友, 直紀","creatorNameLang":"ja"},{"creatorName":"オオトモ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Otomo, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"安部, 千秋","creatorNameLang":"ja"},{"creatorName":"アベ, チアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Abe, Chiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"白井, 斉","creatorNameLang":"ja"},{"creatorName":"シライ, タダシ","creatorNameLang":"ja-Kana"},{"creatorName":"Shirai, Tadashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中田, 栄司","creatorNameLang":"ja"},{"creatorName":"ナカタ, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakata, Eiji","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"堀, 均","creatorNameLang":"ja"},{"creatorName":"ホリ, ヒトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Hori, Hitoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"堀","familyNameLang":"ja"},{"familyName":"ホリ","familyNameLang":"ja-Kana"},{"familyName":"Hori","familyNameLang":"en"}],"givenNames":[{"givenName":"均","givenNameLang":"ja"},{"givenName":"ヒトシ","givenNameLang":"ja-Kana"},{"givenName":"Hitoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"113","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10773/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/10773/profile-ja.html"},{"nameIdentifier":"90119008","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90119008"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2011-03-03"}],"displaytype":"detail","filename":"EID188358.pdf","filesize":[{"value":"274 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2001113/files/EID188358.pdf"},"version_id":"cdca65de-dc87-477f-ba16-9514301ce7c6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antioxidant","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Acyclic tocopherol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Antiatherosclerosis drug","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phytyl quinol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chick embryo chorioallantoic membrane","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Isoprenomics","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"イソプレン側鎖を有する植物成分の ex vivo 有機合成とその生理活性の評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"イソプレン側鎖を有する植物成分の ex vivo 有機合成とその生理活性の評価","subitem_title_language":"ja"},{"subitem_title":"イソプレン ソクサ オ ユウスル ショクブツ セイブン ノ ex vivo ユウキ ゴウセイ ト ソノ セイリ カッセイ ノ ヒョウカ","subitem_title_language":"ja-Kana"}]},"item_type_id":"40001","owner":"7","path":["1713853297799","1716363996082"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-03-03"},"publish_date":"2011-03-03","publish_status":"0","recid":"2001113","relation_version_is_last":true,"title":["イソプレン側鎖を有する植物成分の ex vivo 有機合成とその生理活性の評価"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-14T04:04:57.549056+00:00"}