{"created":"2024-10-15T12:27:44.134314+00:00","id":2001353,"links":{},"metadata":{"_buckets":{"deposit":"345a62de-ffa9-4e27-87c2-153b7edc63ed"},"_deposit":{"created_by":7,"id":"2001353","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2001353"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02001353","sets":["1713853213384:1713853295607"]},"author_link":["1645","1700","1579","1577","1532"],"item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"244","bibliographicPageStart":"237","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose : Nicorandil opens adenosine triphosphate-sensitive potassium (KATP)\nchannels in the cardiovascular system and is being increasingly used for the treatment\nof angina pectoris. In the present study, we tested whether intravenous anesthetic agent\nketamine affected nicorandil-induced native vascular KATP channel activation. Methods :\nWe used excised inside-out patch clamp configurations to investigate the direct effects\nof ketamine racemate and S-(+)-ketamine on the activities of KATP channels in cultured\nrat aortic smooth muscle cells. Furthermore, we also investigated whether intracellular\nMgADP could modulate ketamine inhibition. Results : Nicorandil significantly activated\nKATP channel activity, whereas this channel activity was completely blocked by glibenclamide,\na specific KATP channel blocker. Ketamine racemate inhibited the nicorandil induced\nKATP channel activity (IC50=34 1M, n=14), but S-(+)-ketamine was less potent than ketamine\nracemate in blocking nicorandil induced KATP channel activities (IC50=226 7M,\nn=10). Application of MgADP to the intracellular side of the channel was able to decrease\nthe inhibitory potency of ketamine racemate on nicorandil induced KATP channel activities.\nConclusions : Our results indicate that ketamine inhibits nicorandil induced KATP channel\nactivities in a dose dependent and stereoselective manner. Furthermore, increase of\nintracellularMgADP attenuates the inhibitory potency of ketamine racemate.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html"}]},"item_1723180141928":{"attribute_name":"item_1723180141928","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"233661"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河野, 崇","creatorNameLang":"ja"},{"creatorName":"カワノ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawano, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"田中, 克哉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yin, hua","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"江口, 覚","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1700","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河野, 裕明","creatorNameLang":"ja"},{"creatorName":"カワノ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawano, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"髙橋, 章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中屋, 豊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1577","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大下, 修造","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1532","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2011-12-13"}],"displaytype":"detail","filename":"LID201112132005.pdf","filesize":[{"value":"537 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2001353/files/LID201112132005.pdf"},"version_id":"cc94cca6-4761-42fc-b93f-5dc4f28295bd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"intravenous anesthetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ketamine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nicorandil","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"potassium channel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"patch-clamp configuration","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of ketamine on nicorandil induced ATP-sensitive potassium channel activity in cell line derived from rat aortic smooth muscle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of ketamine on nicorandil induced ATP-sensitive potassium channel activity in cell line derived from rat aortic smooth muscle","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-12-13"},"publish_date":"2011-12-13","publish_status":"0","recid":"2001353","relation_version_is_last":true,"title":["Effects of ketamine on nicorandil induced ATP-sensitive potassium channel activity in cell line derived from rat aortic smooth muscle"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T01:29:44.940945+00:00"}