{"created":"2024-10-22T01:53:06.652988+00:00","id":2001574,"links":{},"metadata":{"_buckets":{"deposit":"a209f1f1-798d-4eae-ba73-b6404ee809f6"},"_deposit":{"created_by":7,"id":"2001574","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2001574"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02001574","sets":["1713829974766:1713854681789:1716364517058:1716365669434","1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["454","343","453","1645","1532"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"婦人科腹腔鏡下手術でニューロキニン1受容体拮抗薬アプレピタントは術後の嘔気・嘔吐を減少させる","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"NK-1 receptor antagonism decreases PONV","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"251","bibliographicPageStart":"246","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose : Post-operative nausea and vomiting (PONV) remains the most frequently reported patient complaint after anesthesia. Aprepitant is the first neurokinin-1(NK1) receptor antagonism available for use as an antiemetic. We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery. Methods : Sixty four patients receiving general anesthesia for laparoscopic gynecological surgery were randomly assigned to either receive a preoperative dose of 80mg aprepitant or no drug. Efficacy was assessed in 2 and 24 hours after surgery. Primary and secondary endpoints were analyzed for the time intervals 0-2 hours (acute phase) and 2-24 hours (delayed phase). Vomiting, nausea, use of rescue anti-emetic, and visual analog scale (VAS) were assessed. Nausea was assessed on a 4-point scale, from 0 to 3. Results : Sixty patients participated in the study. At acute phase, PONV was present in both control and NK1 group and were 63% and 43% respectively. The severity of nausea was much less in the NK1 group. PONV prevalence at delayed phase was present in control but absent in NK1 group 27% vs. 0%, respectively. The amount of pain medication used by patients in the NK1 group was significantly less for diclofenac and pentazocine suggesting increase pain tolerance. Conclusions : Neurokinin-1 receptor antagonism effectively lowered PONV increased pain tolerance, and expedited recovery in patients undergoing laparoscopic gynecological surgery.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2854号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-04-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201506051008.pdf\n論文本文 : LID201506051009.pdf\n本論文は，著者Nami Kakutaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1250号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.58.246"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.58.246","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"266462"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"角田, 奈美","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"堤, 保夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ホリカワ, ヨウスケ","creatorNameLang":"ja"},{"creatorName":"ホリカワ, ヨウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Horikawa, Yousuke T.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"河野, 裕明","creatorNameLang":"ja"},{"creatorName":"カワノ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawano, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"木下, 倫子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 克哉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大下, 修造","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1532","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-06-06"}],"displaytype":"detail","filename":"LID201506051008.pdf","filesize":[{"value":"232 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2001574/files/LID201506051008.pdf"},"version_id":"16f3d0f9-ce2e-4874-abb4-23a0a071ce92"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-06-06"}],"displaytype":"detail","filename":"LID201506051009.pdf","filesize":[{"value":"142 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2001574/files/LID201506051009.pdf"},"version_id":"9fa7e546-0641-43ce-a023-1ccc580edf02"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"neurokinin-1 receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"post-operative nausea and vomiting","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aprepitant","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"laparoscopic gynecological surgery","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628","1716365669434"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-12-07"},"publish_date":"2011-12-07","publish_status":"0","recid":"2001574","relation_version_is_last":true,"title":["Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-20T06:08:11.526956+00:00"}