{"created":"2024-10-22T01:53:29.090494+00:00","id":2001579,"links":{},"metadata":{"_buckets":{"deposit":"8e944000-10d9-41d0-8185-005ad0b4e13c"},"_deposit":{"created_by":7,"id":"2001579","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2001579"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02001579","sets":["1713829974766:1713854681789:1716364517058:1716365669729","1713853213384:1713853295607"]},"author_link":["1524","345","438","1453"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"45","bibliographicPageStart":"39","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim : Particle-mediated transfection is known as an efficient method of nonviral\ngene transfer. Flt3 ligand (FL) is a growth factor for hematopoietic progenitors ; it\npromotes the growth of dendritic cells (DC). DCs are powerful antigen-presenting cells\n(APCs) and show a remarkable capacity to stimulate antigen-specific T-cell responses.\nIn this study, we intended to investigate the suppressive effect on tumor growth by gene\ngun-mediated transfer of FL in a murine model. Methods : C57BL/6J mice were injected\nintradermally with MCA205 cells. DNA (pNGVL-hFLex)-coated gold particles were delivered\nto themouse skin surrounding the target tumor. The expression of FL was determined\nby RT-PCR. Analyses by immunohistochemistry and fluorescence-activated cell\nsorter (FACS) revealed an increase in the number of DC after treatment with FL. Results :\nGene gun-mediated pNGVL-hFLex transfer significantly inhibited the growth of the\nMCA205 tumor. FL transfer markedly increased the number of CD11c+ DCs in the tumor\ntissue. Further, the FL-transfected mice exhibited a significantly higher number of CD80+\nMHC-II cells. Conclusion : We successfully performed FL therapy using an in vivo gene\ngun in order to effectively mobilize DCs in situ and induce suppressive immunity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"248981"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"阿部, 彰子","creatorNameLang":"ja"},{"creatorName":"アベ, アキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Abe, 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Yasuyo","creatorNameLang":"en"}],"familyNames":[{"familyName":"西條","familyNameLang":"ja"},{"familyName":"サイジョウ","familyNameLang":"ja-Kana"},{"familyName":"Saijo","familyNameLang":"en"}],"givenNames":[{"givenName":"康代","givenNameLang":"ja"},{"givenName":"ヤスヨ","givenNameLang":"ja-Kana"},{"givenName":"Yasuyo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1453","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"379925/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/379925/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"苛原, 稔","creatorNameLang":"ja"},{"creatorName":"イラハラ, ミノル","creatorNameLang":"ja-Kana"},{"creatorName":"Irahara, 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fibrosarcoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Gene gun-mediated skin transfection with FL gene suppresses the growth of murine fibrosarcoma","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716365669729"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-12-08"},"publish_date":"2011-12-08","publish_status":"0","recid":"2001579","relation_version_is_last":true,"title":["Gene gun-mediated skin transfection with FL gene suppresses the growth of murine fibrosarcoma"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:01:25.895901+00:00"}