{"created":"2024-10-23T10:01:51.068837+00:00","id":2001995,"links":{},"metadata":{"_buckets":{"deposit":"4cd630be-461f-4b3e-8f6c-9c4e0604bdfe"},"_deposit":{"created_by":7,"id":"2001995","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2001995"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02001995","sets":["1713829974766:1713854682253:1716422254419:1716424780874","1713853213384:1713853295607"]},"author_link":["1215"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Proteomics approach for the mechanism of sex determination","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-12-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5-6","bibliographicPageEnd":"171","bibliographicPageStart":"168","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"四国医学雑誌","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"SRY （sex determining region on the Y chromosome） was a gene isolated as the testis determining factor on the Y chromosome in １９９０．The gene consisted of single exon and encodes a ２０４ amino acid protein. Since SRY protein has a HMG domain, which functions as DNA binding domain, it has been considered to be a transcription factor. Direct target of SRY, however, have not yet identified for １４ years.\nIn this study, we have performed a proteomics approach to analyze the function of SRY. Twodimensional gel electrophoresis after over expression of SRY showed considerable down regulation in many proteins. Among the proteins, mitochondrial ６０‐kDa heat shock protein （HSP６０） and probable protein disulfide isomerase （ER６０） remarkably decreased. Since they were reported to be associated with cell proliferation and differentiation, we investigated the effects of SRY on cell cycle profiles. It was shown that the over‐expression of SRY negatively regulated the cell growth with significant S or G２／M arrest of cell cycle.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"徳島医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00373699","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00102041","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"四国医学雑誌 : http://www.tokushima-u.ac.jp/med/research/shikoku_acta_medica.html"}]},"item_1723180141928":{"attribute_name":"item_1723180141928","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"134576"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 陽一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1215","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"新家, 利一","creatorNameLang":"ja"},{"creatorName":"シンカ, トシカツ","creatorNameLang":"ja-Kana"},{"creatorName":"Shinka, Toshikatsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"陳, 剛","creatorNameLang":"ja"},{"creatorName":"Chen, Gang","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"閻, 洪涛","creatorNameLang":"ja"},{"creatorName":"Yan, Hong-Tao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"坂本, 梢","creatorNameLang":"ja"},{"creatorName":"サカモト, コズエ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakamoto, Kozue","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"楊, 新軍","creatorNameLang":"ja"},{"creatorName":"Yang, Xin‐Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"梅野, 真由美","creatorNameLang":"ja"},{"creatorName":"ウメノ, マユミ","creatorNameLang":"ja-Kana"},{"creatorName":"Umeno, Mayumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中堀, 豊","creatorNameLang":"ja"},{"creatorName":"ナカホリ, ユタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakahori, Yutaka","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2012-08-24"}],"displaytype":"detail","filename":"LID201208241005.pdf","filesize":[{"value":"422 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2001995/files/LID201208241005.pdf"},"version_id":"26194720-8573-4c9c-9552-b39e70eebb73"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SRY","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sex determination","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Y chromosome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"proteomics","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"性分化と精子形成機構に対するプロテオミクスからのアプローチ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"性分化と精子形成機構に対するプロテオミクスからのアプローチ","subitem_title_language":"ja"},{"subitem_title":"セイブンカ ト セイシ ケイセイ キコウ ニ タイスル プロテオミクス カラノ アプローチ","subitem_title_language":"ja-Kana"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716424780874"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-08-24"},"publish_date":"2012-08-24","publish_status":"0","recid":"2001995","relation_version_is_last":true,"title":["性分化と精子形成機構に対するプロテオミクスからのアプローチ"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T01:34:24.326974+00:00"}