{"created":"2024-10-23T10:08:42.538871+00:00","id":2002094,"links":{},"metadata":{"_buckets":{"deposit":"1e5b5339-0cf1-4f91-b98e-26efe8ec7f92"},"_deposit":{"created_by":7,"id":"2002094","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002094"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002094","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["702","1253","387","265","792","193","1266","467","603"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"脂肪由来幹細胞の栄養因子を介した肝傷害に対しての保護効果","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-10-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"168","bibliographicPageStart":"162","bibliographicVolumeNumber":"180","bibliographic_titles":[{"bibliographic_title":"Journal of Surgical Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nIn this study we investigated whether adipose-derived stem cells (ADSCs) had any beneficial protective effects on liver injury and regeneration in vivo. Moreover, we examined whether ADSCs protect hepatocytes by trophic molecules.\nMaterials and Methods\nWe transplanted ADSCs into mice after 70% hepatectomy (Hx) and ischemia-reperfusion (I/R), and observed liver injury and regeneration after reperfusion. We co-cultured hepatocytes with ADSCs using a Transwell System for seven days and evaluated the viabilities of hepatocytes and the cytokine levels in the culture medium. Bevacizumab was used in order to confirm the effect of VEGF on hepatocytes.\nResults\nADSCs improved serum liver function at six hours after reperfusion in a non-lethal model and stimulated liver regeneration at 24 hours after reperfusion in a lethal model. VEGF levels in the culture medium increased by co-culture ADSCs with hepatocytes. ADSCs improved the viabilities of hepatocytes. The inhibited production of VEGF by bevacizumab did not affect the viability of hepatocytes.\nConclusions\nADSCs were able to ameliorate liver injury and stimulate liver regeneration in subsequent Hx and I/R injured model mice. Furthermore, hepatocytes were protected by the trophic molecules of the ADSCs. However, such protective effects might be provided by mechanisms other than VEGF signaling.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00224804","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00708021","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"dissertation_number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2618号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-05-23"}]},"item_1714461137393":{"attribute_name":"item_1714461137393","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201308190003.pdf\n論文本文 : LID201405260001.pdf\n本論文は, 著者Yu Saitoの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"item_1718868303842","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1163号"}]},"item_1722929371688":{"attribute_name":"item_1722929371688","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.jss.2012.10.009"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jss.2012.10.009","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"item_1723180141928","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"280786"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"齋藤, 裕","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 光生","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1253","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宇都宮, 徹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池本, 哲也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 眞一郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森根, 裕二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"居村, 暁","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 大樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"スギモト, コウジ","creatorNameLang":"ja"},{"creatorName":"スギモト, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugimoto, Kouji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岩橋, 衆一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"アサノマ, ミチヒト","creatorNameLang":"ja"},{"creatorName":"アサノマ, ミチヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Asanoma, Michihito","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2013-08-19"}],"displaytype":"detail","filename":"LID201308190003.pdf","filesize":[{"value":"175 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002094/files/LID201308190003.pdf"},"version_id":"2611500b-a03d-4c99-ad5b-b2aefc2bbcc2"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-05-26"}],"displaytype":"detail","filename":"LID201405260001.pdf","filesize":[{"value":"489 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002094/files/LID201405260001.pdf"},"version_id":"3ad6a124-4cf3-47a1-a288-bd1f48683b81"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adipose derived stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatocytes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Vascular endothelial growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The protective effect of adipose-derived stem cells against liver injury by trophic molecules","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The protective effect of adipose-derived stem cells against liver injury by trophic molecules","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-19"},"publish_date":"2013-08-19","publish_status":"0","recid":"2002094","relation_version_is_last":true,"title":["The protective effect of adipose-derived stem cells against liver injury by trophic molecules"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-23T10:08:51.217193+00:00"}