{"created":"2024-10-23T10:20:24.911286+00:00","id":2002241,"links":{},"metadata":{"_buckets":{"deposit":"322a57c6-0a1a-4a86-9082-1724fa84d03c"},"_deposit":{"created_by":7,"id":"2002241","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002241"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002241","sets":["1713829974766:1713854681789:1716364516449:1716365580232","1713853213384:1713853295607"]},"author_link":["564","340","183","309"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"14","bibliographicPageStart":"1","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The obesity epidemic is a global public health concern that increases the likelihood of morbidity and mortality of metabolic and cardiovascular disease (CVD) and threatens to reduce life expectancy around the world. The concept of the metabolic syndrome (MetS) takes into account that visceral fat plays an essential role in the development of metabolic and cardiovascular diseases. However, MetS cannot be used to assess global CVD risk but is at best one more modifiable CVD risk factor. Thus, global cardiometabolic risk (the global risk of cardiovascular disease resulting from traditional risk factors combined with the additional contribution of the metabolic syndrome and/or insulin resistance) should be considered individually. There is solid evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as MetS. Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. Also, ectopic fat deposition could be deteriorated in the heart components such as (1) circulatory and locally recruited fat, (2) intra- and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is reviewed and also discussed are potential underlying mechanisms including adipocytokine, insulin resistance and lipotoxicity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"260046"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"シマブクロ, ミチオ","creatorNameLang":"ja"},{"creatorName":"シマブクロ, ミチオ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimabukuro, Michio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小塚, 智沙代","creatorNameLang":"ja"},{"creatorName":"コズカ, チサヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Kozuka, Chisayo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"平良, 伸一郎","creatorNameLang":"ja"},{"creatorName":"タイラ, シンイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Taira, Shin-ichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"屋比久, 浩市","creatorNameLang":"ja"},{"creatorName":"ヤビク, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Yabiku, Koichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Dagvasumberel, Munkhbaatar","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシダ, マサヨシ","creatorNameLang":"ja"},{"creatorName":"イシダ, マサヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishida, Masayoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツモト, サチコ","creatorNameLang":"ja"},{"creatorName":"マツモト, サチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Sachiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"八木, 秀介","creatorNameLang":"ja"},{"creatorName":"ヤギ, シュウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Yagi, Shusuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"八木","familyNameLang":"ja"},{"familyName":"ヤギ","familyNameLang":"ja-Kana"},{"familyName":"Yagi","familyNameLang":"en"}],"givenNames":[{"givenName":"秀介","givenNameLang":"ja"},{"givenName":"シュウスケ","givenNameLang":"ja-Kana"},{"givenName":"Shusuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"340","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"178255/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/178255/profile-ja.html"},{"nameIdentifier":"00507650","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00507650"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"福田, 大受","creatorNameLang":"ja"},{"creatorName":"フクダ, ダイジュ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuda, Daiju","creatorNameLang":"en"}],"familyNames":[{"familyName":"福田","familyNameLang":"ja"},{"familyName":"フクダ","familyNameLang":"ja-Kana"},{"familyName":"Fukuda","familyNameLang":"en"}],"givenNames":[{"givenName":"大受","givenNameLang":"ja"},{"givenName":"ダイジュ","givenNameLang":"ja-Kana"},{"givenName":"Daiju","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"564","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40637568","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40637568"}]},{"creatorNames":[{"creatorName":"ヤマカワ, ケン","creatorNameLang":"ja"},{"creatorName":"ヤマカワ, ケン","creatorNameLang":"ja-Kana"},{"creatorName":"Yamakawa, Ken","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒガ, モリタケ","creatorNameLang":"ja"},{"creatorName":"ヒガ, モリタケ","creatorNameLang":"ja-Kana"},{"creatorName":"Higa, Moritake","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"添木, 武","creatorNameLang":"ja"},{"creatorName":"ソエキ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Soeki, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"添木","familyNameLang":"ja"},{"familyName":"ソエキ","familyNameLang":"ja-Kana"},{"familyName":"Soeki","familyNameLang":"en"}],"givenNames":[{"givenName":"武","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"183","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"121162/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/121162/profile-ja.html"},{"nameIdentifier":"60393211","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60393211"}]},{"creatorNames":[{"creatorName":"ヨシダ, ヒサシ","creatorNameLang":"ja"},{"creatorName":"ヨシダ, ヒサシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Hisashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"益崎, 裕章","creatorNameLang":"ja"},{"creatorName":"マスザキ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Masuzaki, Hiroaki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"},{"creatorName":"サタ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Sata, Masataka","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐田","familyNameLang":"ja"},{"familyName":"サタ","familyNameLang":"ja-Kana"},{"familyName":"Sata","familyNameLang":"en"}],"givenNames":[{"givenName":"政隆","givenNameLang":"ja"},{"givenName":"マサタカ","givenNameLang":"ja-Kana"},{"givenName":"Masataka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"173932/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/173932/profile-ja.html"},{"nameIdentifier":"80345214","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80345214"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-02-26"}],"displaytype":"detail","filename":"LID201402262001.pdf","filesize":[{"value":"1.23 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002241/files/LID201402262001.pdf"},"version_id":"7937ff7b-1542-4d3f-8aa5-f33e6617ca93"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"obesity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cardiovascular disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetes mellitus","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ectopic fat deposition and global cardiometabolic risk : New paradigm in cardiovascular medicine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ectopic fat deposition and global cardiometabolic risk : New paradigm in cardiovascular medicine","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716365580232"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-02-26"},"publish_date":"2014-02-26","publish_status":"0","recid":"2002241","relation_version_is_last":true,"title":["Ectopic fat deposition and global cardiometabolic risk : New paradigm in cardiovascular medicine"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-10T06:41:49.755983+00:00"}