{"created":"2024-10-25T07:03:02.505594+00:00","id":2002335,"links":{},"metadata":{"_buckets":{"deposit":"491d0ec0-35fa-4200-83cc-0c93e23097c5"},"_deposit":{"created_by":7,"id":"2002335","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002335"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002335","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["571","1253","1521"],"control_number":"2002335","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Rbpjの欠損はCD4陽性T細胞によるIL-22産生を抑制することで実験的自己免疫性網膜ブドウ膜炎の症状を軽減させる","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Abrogation of Rbpj attenuates uveoretinitis","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"e89266","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"PLOS ONE","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Experimental autoimmune uveoretinitis (EAU) is an organ-specific T cell-mediated disease induced by immunizing mice with interphotoreceptor retinoid binding protein (IRBP). Autoaggressive CD4+ T cells are the major pathogenic population for EAU. We investigated the contribution of Notch signaling in T cells to EAU pathogenesis because Notch signaling regulates various aspects of CD4+ T cell functions. Rbpj is required for Notch signaling, and Rbpj deficiency in T cells inhibited EAU disease severity. The amelioration of EAU in T cell-specific Rbpj-deficient mice correlated with low levels of IL-22 production from CD4+ T cells, although IRBP-specific CD4+ T cell proliferation and Th17 differentiation were unaffected. Administration of recombinant IL-22 during the late phase, but not the early phase, of EAU increased EAU clinical scores in T cell-specific Rbpj-deficient mice. Notch inhibition in mice immunized with IRBP with a γ-secretase inhibitor (GSI) suppressed EAU progression, even when GSI was administered as late as 13 days after IRBP immunization. Our data demonstrate that Rbpj/Notch-mediated IL-22 production in T cells has a key pathological role in the late phase of EAU, and suggest that Notch blockade might be a useful therapeutic approach for treating EAU.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"©2014 Bhuyan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2740号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-19"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201405131004.pdf\n論文本文 : LID201405281002.pdf\n本論文は, 著者Zaied Ahmed Bhuyanの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1201号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1371/journal.pone.0089266"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0089266","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"282677"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ブヤ, ザイド アハマド","creatorNameLang":"ja"},{"creatorName":"ブヤ, ザイド アハマド","creatorNameLang":"ja-Kana"},{"creatorName":"Bhuyan, Zaied Ahmed","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アサノマ, ミチヒト","creatorNameLang":"ja"},{"creatorName":"アサノマ, ミチヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Asanoma, Michihito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岩田, 明子","creatorNameLang":"ja"},{"creatorName":"イワタ, アキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, Akiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"石舟, 智恵子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"マエカワ, ヨウイチ","creatorNameLang":"ja"},{"creatorName":"マエカワ, ヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Maekawa, Yoichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"島田, 光生","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1253","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安友, 康二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1521","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-05-13"}],"displaytype":"detail","filename":"LID201405131004.pdf","filesize":[{"value":"183 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002335/files/LID201405131004.pdf"},"version_id":"98336c97-4bd4-4df5-ac25-18395c73ced1"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-05-28"}],"displaytype":"detail","filename":"LID201405281002.pdf","filesize":[{"value":"349 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002335/files/LID201405281002.pdf"},"version_id":"9b057a67-de07-4377-a94b-c3e0a6206465"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Notch","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rbpj","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"EAU (Experimental Autoimmune Uveoretinitis)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GSI (γ secretase inhibitor)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-22","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-05-13"},"publish_date":"2014-05-13","publish_status":"0","recid":"2002335","relation_version_is_last":true,"title":["Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-11-13T06:32:03.642091+00:00"}