{"created":"2024-10-25T07:26:50.123197+00:00","id":2002637,"links":{},"metadata":{"_buckets":{"deposit":"93ec524d-f4aa-49f3-b35d-22eae046328b"},"_deposit":{"created_by":7,"id":"2002637","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002637"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002637","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["1574","1584"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ラット腎不全初期における心臓リモデリングには心筋タンパク質と脂質の増加が関与している","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1443","bibliographicPageStart":"1433","bibliographicVolumeNumber":"1842","bibliographic_titles":[{"bibliographic_title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chronic kidney disease (CKD) is associated with increased risks of cardiovascular morbidity and mortality. Cardiac remodeling including myocardial fibrosis and hypertrophy is frequently observed in CKD patients. In this study, we investigate the mechanism involved in cardiac hypertrophy associated with CKD using a rat model, by morphological and chemical component changes of the hypertrophic and non-hypertrophic hearts. Sprague–Dawley rats were 4/5 nephrectomized (Nx) at 11 weeks of age and assigned to no treatment and treatment with AST-120,which was reported to affect the cardiac damage, at 18 weeks of age. At 26 weeks of age, the rats were euthanized under anesthesia, and biochemical tests as well as analysis of cardiac condition were performed by histological and spectrophotometric methods. Cardiac hypertrophy and CKD were observed in 4/5 Nx rats even though vascular calcification and myocardial fibrosis were not detected. The increasing myocardial protein was confirmed in hypertrophic hearts by infrared spectroscopy. The absorption of amide I and other protein bands in hypertrophic hearts increased at the same position as in normal cardiac absorption. Infrared spectra also showed that lipid accumulation was also detected in hypertrophic heart. Conversely, the absorptions of protein were obviously reduced in the myocardium of non-hypertrophic heart with CKD compared to that of hypertrophic heart. The lipid associated absorption was also decreased in non-hypertrophic heart. Our results suggest that cardiac remodeling associated with relatively early-stage CKD may be suppressed by reducing increased myocardial protein and ameliorating cardiac lipid load.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09254439","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10779707","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11522998","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2848号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201505251021.pdf\n論文本文 : k2848_fulltext.pdf\n本論文は,著者Mieko Kuwaharaの学位論文として提出され, 学位審査・授与の対象となっている。\n著者の申請により要約(2015-05-26公開)に替えて論文全文を公開(2020-03-18)\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第226号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.bbadis.2014.04.026"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbadis.2014.04.026","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"282994"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"桑原, 三恵子","creatorNameLang":"ja"},{"creatorName":"クワハラ, ミエコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kuwahara, Mieko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"バンナイ, ケンジ","creatorNameLang":"ja"},{"creatorName":"バンナイ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Bannai, Kenji","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"瀬川, 博子","creatorNameLang":"ja"},{"creatorName":"セガワ, ヒロコ","creatorNameLang":"ja-Kana"},{"creatorName":"Segawa, Hiroko","creatorNameLang":"en"}],"familyNames":[{"familyName":"瀬川","familyNameLang":"ja"},{"familyName":"セガワ","familyNameLang":"ja-Kana"},{"familyName":"Segawa","familyNameLang":"en"}],"givenNames":[{"givenName":"博子","givenNameLang":"ja"},{"givenName":"ヒロコ","givenNameLang":"ja-Kana"},{"givenName":"Hiroko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1584","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60146/profile-ja.html","nameIdentifierScheme":"徳島大学 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Ken-ichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"宮本","familyNameLang":"ja"},{"familyName":"ミヤモト","familyNameLang":"ja-Kana"},{"familyName":"Miyamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"賢一","givenNameLang":"ja"},{"givenName":"ケンイチ","givenNameLang":"ja-Kana"},{"givenName":"Ken-ichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1574","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60127/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60127/profile-ja.html"},{"nameIdentifier":"70174208","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70174208"}]},{"creatorNames":[{"creatorName":"ヤマト, ヒデユキ","creatorNameLang":"ja"},{"creatorName":"ヤマト, ヒデユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamato, Hideyuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-05-26"}],"displaytype":"detail","filename":"LID201505251021.pdf","filesize":[{"value":"191 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002637/files/LID201505251021.pdf"},"version_id":"577052b9-31bb-404e-af4e-6cd78037394e"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-18"}],"displaytype":"detail","filename":"k2848_fulltext.pdf","filesize":[{"value":"3.12 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accumulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Cardiac remodeling associated with protein increase and lipid accumulation in early-stage chronic kidney disease in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cardiac remodeling associated with protein increase and lipid accumulation in early-stage chronic kidney disease in rats","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-25"},"publish_date":"2015-05-25","publish_status":"0","recid":"2002637","relation_version_is_last":true,"title":["Cardiac remodeling associated with protein increase and lipid accumulation in early-stage chronic kidney disease in rats"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T09:17:47.195285+00:00"}