{"created":"2024-10-25T07:28:38.978637+00:00","id":2002656,"links":{},"metadata":{"_buckets":{"deposit":"7e3a8b72-fff8-4932-88f7-b47332403661"},"_deposit":{"created_by":7,"id":"2002656","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002656"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002656","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["697","377","1582","598","170","323","1586"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"C2C12筋管細胞においてフラボンはLPS誘導性atrogin-1/MAFbxの発現を抑制する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Flavones Prevent LPS-Induced Muscle Atrophy","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"194","bibliographicPageStart":"188","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Journal of Nutritional Science and Vitaminology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Muscle atrophy is a complex process that occurs as a consequence of various stress events. Muscle atrophy-associated genes (atrogenes) such as atrogin-1/MAFbx and MuRF-1 are induced early in the atrophy process, and the increase in their expression precedes the loss of muscle weight. Although antioxidative nutrients suppress atrogene expression in skeletal muscle cells, the inhibitory effects of flavonoids on inflammation-induced atrogin-1/MAFbx expression have not been clarified. Here, we investigated the inhibitory effects of flavonoids on lipopolysaccharide (LPS)-induced atrogin-1/MAFbx expression. We examined whether nine flavonoids belonging to six flavonoid categories inhibited atrogin-1/MAFbx expression in mouse C2C12 myotubes. Two major flavones, apigenin and luteolin, displayed potent inhibitory effects on atrogin-1/MAFbx expression. The pretreatment with apigenin and luteolin significantly prevented the decrease in C2C12 myotube diameter caused by LPS stimulation. Importantly, the pretreatment of LPS-stimulated myoblasts with these flavones significantly inhibited LPS-induced JNK phosphorylation in C2C12 myotubes, resulting in the significant suppression of atrogin-1/MAFbx promoter activity. These results suggest that apigenin and luteolin, prevent LPS-mediated atrogin-1/MAFbx expression through the inhibition of the JNK signaling pathway in C2C12 myotubes. Thus, these flavones, apigenin and luteolin, may be promising agents to prevent LPS-induced muscle atrophy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Vitamin Society of Japan","subitem_publisher_language":"en"},{"subitem_publisher":"Japan Society of Nutrition and Food Science","subitem_publisher_language":"en"},{"subitem_publisher":"Center for Academic Publications Japan","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© The Vitamin Society of Japan, Japan Society of Nutrition and Food Science","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"18817742","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"03014800","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00703822","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2813号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨 : LID201505281004.pdf\n審査要旨 : LID201505281005.pdf\n論文本文 : LID201506091001.pdf\n本論文は, 著者Chieko SHIOTAの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部(口腔科学専攻)"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第395号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3177/jnsv.61.188"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3177/jnsv.61.188","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"295244"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"塩田, 智子","creatorNameLang":"ja"},{"creatorName":"シオタ, チエコ","creatorNameLang":"ja-Kana"},{"creatorName":"Shiota, Chieko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"安倍, 知紀","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"697","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川合, 暢彦","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"377","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"オオノ, アヤコ","creatorNameLang":"ja"},{"creatorName":"オオノ, アヤコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohno, Ayako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"(手嶋)近藤, 茂忠","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 博世","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"598","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"寺尾, 純二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 栄二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"323","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二川, 健","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1586","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-05-29"}],"displaytype":"detail","filename":"LID201505281004.pdf","filesize":[{"value":"157 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002656/files/LID201505281004.pdf"},"version_id":"ada75507-0b23-48ca-901d-9f0cff106c0e"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-05-29"}],"displaytype":"detail","filename":"LID201505281005.pdf","filesize":[{"value":"362 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2002656/files/LID201505281005.pdf"},"version_id":"3394399a-2cf6-415d-a20f-e809b8936569"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-06-10"}],"displaytype":"detail","filename":"LID201506091001.pdf","filesize":[{"value":"757 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002656/files/LID201506091001.pdf"},"version_id":"ca52d011-5640-485d-aa7f-60c8542ea201"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"flavones","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LPS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"muscle atrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"JNK","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Flavones inhibit LPS-induced atrogin-1/MAFbx expression in mouse C2C12 skeletal myotubes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Flavones inhibit LPS-induced atrogin-1/MAFbx expression in mouse C2C12 skeletal myotubes","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-28"},"publish_date":"2015-05-28","publish_status":"0","recid":"2002656","relation_version_is_last":true,"title":["Flavones inhibit LPS-induced atrogin-1/MAFbx expression in mouse C2C12 skeletal myotubes"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T07:28:52.025643+00:00"}