{"created":"2024-10-25T07:28:46.916971+00:00","id":2002657,"links":{},"metadata":{"_buckets":{"deposit":"cdb11df7-b29b-4268-a459-f45b45135586"},"_deposit":{"created_by":7,"id":"2002657","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002657"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002657","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["569","410","1720","593","170","203"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ヒト歯肉線維芽細胞における酸化ストレスに対するレスベラトロール，ケルセチン，及びN-アセチルシステインの生物学的影響","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"227","bibliographicPageStart":"220","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In periodontitis, production of reactive oxygen species (ROS) by neutrophils induces oxidative stress and deteriorates surrounding tissues. Antioxidants reduce damage caused by ROS and are used to treat diseases involving oxidative stress. This study summarizes the different effects of resveratrol, quercetin, and N-acetylcysteine (NAC) on human gingival fibroblasts (HGFs) under oxidative stress induced by hydrogen peroxide. Real-time cytotoxicity analyses reveals that resveratrol and quercetin enhanced cell proliferation even under oxidative stress. Of the antioxidants tested, resveratrol is the most effective at inhibiting ROS production. HGFs incubated with resveratrol and quercetin up-regulate the transcription of type I collagen gene after 3 h, but only resveratrol sustained this up-regulation for 24 h. A measurement of the oxygen consumption rate (OCR, mitochondrial respiration) shows that resveratrol generates the highest maximal respiratory capacity, followed by quercetin and NAC. Simultaneous measurement of OCR and the extracellular acidification rate (non-mitochondrial respiration) reveals that resveratrol and quercetin induce an increase in mitochondrial respiration when compared with untreated cells. NAC treatment consumes less oxygen and enhances more non-mitochondrial respiration. In conclusion, resveratrol is the most effective antioxidant in terms of real-time cytotoxicity analysis, reduction of ROS production, and enhancement of type I collagen synthesis and mitochondrial respiration in HGFs.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"SOCIETY FOR FREE RADICAL RESEARCH JAPAN","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Copyright © 2015 日本酸化ストレス学会(Society for Free Radical Research Japan)","subitem_rights_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"18805086","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"09120009","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10710201","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12091064","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2810号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨 : LID201505291001.pdf\n審査要旨 : LID201505291002.pdf\n論文本文 : LID201507171007.pdf\n本論文は, 著者Rita Cristina Orihuela-Camposの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第392号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3164/jcbn.14-129"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.14-129","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"295271"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"オリウエラ カンポス, リタ クリスティーナ","creatorNameLang":"ja"},{"creatorName":"オリウエラ カンポス, リタ クリスティーナ","creatorNameLang":"ja-Kana"},{"creatorName":"Orihuela Campos, Rita Cristina","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"玉木, 直文","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"569","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"向井, 理恵","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福井, 誠","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三木, かなめ","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"593","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"寺尾, 純二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 博夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"203","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-05-29"}],"displaytype":"detail","filename":"LID201505291001.pdf","filesize":[{"value":"113 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002657/files/LID201505291001.pdf"},"version_id":"1f13d6b9-be20-4f1e-971d-091214c90de3"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-05-29"}],"displaytype":"detail","filename":"LID201505291002.pdf","filesize":[{"value":"384 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2002657/files/LID201505291002.pdf"},"version_id":"7611c9a0-2642-490a-9ff1-9a7f34089a66"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-07-18"}],"displaytype":"detail","filename":"LID201507171007.pdf","filesize":[{"value":"1.78 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002657/files/LID201507171007.pdf"},"version_id":"259762f7-dcb8-4a2a-a976-b2907c7cf5bb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"human gingival fibroblasts","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"periodontitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"resveratrol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"quercetin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"N-acetylcysteine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Biological impacts of resveratrol, quercetin, and N-acetylcysteine on oxidative stress in human gingival fibroblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Biological impacts of resveratrol, quercetin, and N-acetylcysteine on oxidative stress in human gingival fibroblasts","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-29"},"publish_date":"2015-05-29","publish_status":"0","recid":"2002657","relation_version_is_last":true,"title":["Biological impacts of resveratrol, quercetin, and N-acetylcysteine on oxidative stress in human gingival fibroblasts"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T07:28:58.898184+00:00"}